This federal Project Grant award with ID R01MH139216 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The $665,893 grant supports research to study how hippocampal neural activity during sleep can stabilize or interfere with memories of experiences in different contexts. The key objectives are to: 1) further develop machine learning techniques to analyze the evolution of hippocampal neural codes during sleep; 2) conduct...
This $588,018 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the neural basis underlying the impact of stress on sleep architecture and its implications for cognitive function. The primary objectives are to determine the role of specific neural pathways from the locus coeruleus and paraventricular nucleus to the preoptic area of the hypothalamus in mediating stress-induced changes in...
This federal Project Grant award from the National Science Foundation's (NSF) Social, Behavioral, and Economic Sciences (CFDA 47.075) program provides $457,860 to the University of California, Irvine to conduct research on how memory consolidation and processing are affected by multiple nights of sleep. The project aims to systematically examine the contribution of sleep over time to memory formation and retention, using a combination of behavioral, physiological, and computational methods....
This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Award (CFDA 47.070) for $850,000 will fund research to understand how sleep and memory are intertwined in the brain by measuring changes in synaptic connections between neurons during sleep. The project will leverage sophisticated recording and statistical tools to observe how synaptic connections evolve during sleep and memory tasks, with the goal of uncovering the mechanisms by which...
The National Institute of Mental Health (NIMH) awarded a $440,000 Project Grant (R21MH134002) to Baylor College of Medicine to study astrocyte ensembles and their role in memory formation. The 2-year grant, starting on August 1, 2023, aims to define the properties of astrocyte engrams - the physical substrate of memory that has been underexplored to date. The research will use specialized mouse models and viral tools developed by the investigators to label and manipulate astrocyte ensembles...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a $424,875 research project titled "Adolescent Trauma Produces Enduring Disruptions in Sleep Architecture that Lead to Increased Risk for Adult Mental Illness." The project aims to: 1) determine if individual differences in sleep profiles following adolescent stress can predict adult behavioral outcomes related to depression and...
The federal Project Grant award R01MH137156, totaling $625,108, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). This grant supports research to investigate the function of the output layers of the lateral entorhinal cortex (LEC) in associative memory formation. The key objectives of the research are to: 1) identify the roles of serotonin inputs to LEC layer 5/6 neurons in associative learning; 2) determine the function...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,537,727 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Trustees of the University of Pennsylvania. This 8-year research program, commencing June 1, 2024, aims to investigate the regulation and function of sleep across early development. Key objectives include: Defining the cellular and circuit properties of sleep/wake regulatory neurons throughout...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Trustees of Columbia University in the City of New York, totaling $338,600 from August 1, 2024 to June 30, 2027. The grant will support research to investigate the neural circuits underlying egocentric and allocentric cognitive maps in humans, which are essential for spatial navigation and memory. The project will use computational modeling and single-neuron...
This National Science Foundation (NSF) Social, Behavioral, and Economic Sciences (CFDA 47.075) Project Grant award provides $160,000 in funding to support a postdoctoral fellowship investigation into how sleep facilitates the integration of new and existing memories. The goal is to understand the brain mechanisms that enable this integration process, which is critical for building knowledge from new information encountered in daily life. The study will use electroencephalography (EEG),...