This federal Project Grant award of $809,312 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to characterize circadian function and its implications for clinical and cognitive functioning in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The study, conducted by Duke University and its subcontractor RTI International, will use gold-standard dim light melatonin onset (DLMO) assessment as well as innovative...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will provide $181,234 to the University Enterprises Corporation at CSUSB to study the impact of preadolescent psychostimulant exposure on sleep neurophysiology and circadian rhythms in an animal model of ADHD. The goal is to break down the complex relationship between early psychostimulant use and ADHD, and whether any effects on sleep...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a $424,875 research project titled "Adolescent Trauma Produces Enduring Disruptions in Sleep Architecture that Lead to Increased Risk for Adult Mental Illness." The project aims to: 1) determine if individual differences in sleep profiles following adolescent stress can predict adult behavioral outcomes related to depression and...
This federal Project Grant award for $729,367, awarded on December 18, 2024 by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to assess the impacts of a 2022 nationwide shortage of immediate-release amphetamine mixed salts prescription stimulant medications on the health and treatment outcomes of youth with Attention-Deficit Hyperactivity Disorder (ADHD). The research team from the Rand Corporation will: 1)...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $826,902 to the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to investigate the dynamic relationships between physical activity, sleep, and circadian rhythms with heterogeneity in clinical symptoms and neurobehavioral functioning in children with attention-deficit/hyperactivity disorder (ADHD). The study will leverage...
This $588,018 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the neural basis underlying the impact of stress on sleep architecture and its implications for cognitive function. The primary objectives are to determine the role of specific neural pathways from the locus coeruleus and paraventricular nucleus to the preoptic area of the hypothalamus in mediating stress-induced changes in...
This $857,216 federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants will be used by Boston Children's Hospital to conduct a longitudinal study examining the neurodevelopmental trajectories and social determinants leading to early symptoms of Attention Deficit Hyperactivity Disorder (ADHD) and disruptive behaviors in children. The study will leverage an existing large, diverse cohort of low-resourced infants seen in an...
This $121,424 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to understand the impact of early sleep disturbance on brain development and neurodevelopmental trajectories in infancy. The project aims to: (1) examine how sleep latency and thalamocortical connectivity may predict diagnostic outcome in infants at varying familial likelihood for autism spectrum disorder (ASD), and (2)...
This $443,263 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 5-year study on the relationship between cannabis use and sleep in women of childbearing age. The research team at Rutgers University will conduct a 60-day prospective study with 100 female cannabis users to characterize the effects of acute cannabis exposure on sleep physiology, including brain activity (EEG), autonomic nervous...
This $187,431 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research at the University of North Carolina at Chapel Hill to investigate how early life sleep disruption interacts with genetic vulnerabilities in Autism Spectrum Disorder (ASD). The research aims to establish developmental sleep disruption as a risk factor for ASD by examining its interaction with the high-confidence ASD risk gene...
This $633,671 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) supports research to evaluate the safety of prescription sleep medications used by children, adolescents, and young adults with ADHD. The study team at Rutgers, The State University of New Jersey will use national administrative claims data spanning 2001-2023 to examine age-specific patterns of sleep medication use and assess the risks of serious adverse events, including suicide attempts, unintentional overdose, cardiovascular complications, and hallucinations. The researchers will also explore whether ADHD or stimulant treatment magnify these medication-related risks. This project aims to generate rigorous safety data to inform evidence-based decision-making by patients, caregivers, and clinicians regarding the pharmacological management of sleep problems in youth with mental health conditions. The award period runs from May 1, 2025 to February 28, 2030.