Project Grant R01MD021656
- The National Institute on Aging awarded the University of Florida $725,528 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on resistance exercise training for older adults with obesity using GLP-1 receptor agonists. The project will evaluate whether progressive, moderate to high-intensity resistance training mitigates muscle loss and strength decline in older adults initiating GLP-1 receptor agonist therapy for obesity treatment. The research addresses...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Adventhealth Orlando $151,816 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a real-world outcomes study of glucagon-like peptide-1 (GLP-1) medicines in type 1 diabetes patients. The project will assess weight loss, kidney disease progression, and major adverse events in type 1 diabetes patients treated with cardioprotective GLP-1 medicines...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Alabama at Birmingham $743,243 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a sequential multiple assignment randomized trial optimizing intensive behavioral therapy for obesity in adults aged 50 to 75 years. The trial will enroll 250 adults with obesity to determine the optimal first-line diet strategy—high-protein versus...
- The Department of Health and Human Services National Institutes of Health National Institute for Minority Health and Health Disparities awarded the University of South Florida $763,585 on July 28, 2026, under the Minority Health and Health Disparities Research program (CFDA 93.307) to conduct a randomized controlled trial evaluating ADAPT+, a multi-family lifestyle intervention designed to promote healthy eating and physical activity behaviors in youth aged 8–12 years with obesity and their...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $744,590 on August 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a factorial experiment optimizing behavioral lifestyle intervention for adults prescribed next-generation anti-obesity medications. The project will recruit 608 adults with obesity or overweight with weight-related comorbidity who are prescribed second-generation...
- The National Institute on Aging awarded Mayo Clinic $443,850 on March 15, 2026, under the Aging Research program (CFDA 93.866) to study the real-world effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications on older adults. Mayo Clinic will use linked electronic health records from the Rochester Epidemiology Project to analyze age differences in GLP-1 RA response across a population-based cohort of 26,442 persons in the upper midwest. The study will test three primary...
- The National Heart, Lung, and Blood Institute awarded Trustees of Boston University (doing business as Boston University Medical Campus) $837,125 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on real-world effects of GLP-1 receptor agonists on cardiovascular-kidney-metabolic syndrome progression and lifetime costs in people with HIV and type 2 diabetes. The research addresses a critical gap in evidence-based guidance for type 2...
- The National Institute on Aging awarded Arizona State University $436,228 on June 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the impact of glucagon-like peptide-1 receptor agonists on sarcopenia in older adults. The research project will measure muscle mass and the mechanisms regulating muscle mass—including muscle protein synthesis and breakdown—using stable isotope tracer methodologies in older patients before and six months after GLP-1 RA treatment. The study will...
- The National Heart, Lung and Blood Institute awarded the University of North Carolina at Chapel Hill $1,505,062 on September 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a factorial trial optimizing dietary adherence in a mobile behavioral weight loss intervention for adults. The award funds a six-month randomized trial enrolling 580 adults in a smartphone-based weight loss program that combines daily calorie goals with mobile dietary self-monitoring...
- The National Heart, Lung, and Blood Institute awarded Mayo Clinic Jacksonville $199,244 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a five-year career development project investigating semaglutide's effects on preclinical cardiovascular disease markers in breast cancer survivors with obesity. The project will conduct a 24-week randomized controlled trial enrolling 50 breast cancer survivors with obesity, comparing lifestyle modification alone to...
The National Institute for Minority Health and Health Disparities awarded the University of Florida $734,785 on September 1, 2026, under the Minority Health and Health Disparities Research program (CFDA 93.307) to conduct a randomized controlled trial examining lifestyle strategies for preserving muscle mass and reducing cardiovascular risk in adults with obesity who initiate GLP-1 receptor agonist therapy. The trial will enroll 670 adults with obesity (BMI 30 or BMI 27 with comorbidity) from different socioeconomic groups within three weeks of their first GLP-1 dose. Participants randomize to either a GLP-1 lifestyle management program based on YMCA of Florida's First Coast evidence-based physical activity and resistance training curriculum, or enhanced usual care consisting of monthly health education workshops plus standard physician guidance. The primary outcome measures 6-month change in lean mass by dual-energy x-ray absorptiometry; secondary outcomes include changes in atherosclerotic cardiovascular disease risk, total lean mass, weight loss, diet quality, physical activity, and self-reported quality of life. The trial addresses an evidence gap identified by professional societies including the American College of Lifestyle Medicine, American Society for Nutrition, Obesity Medicine Association, and Obesity Society, which recommend integrating nutritional management and resistance training for GLP-1 patients despite limited rigorous real-world evidence supporting these recommendations. Place of performance is Gainesville, Florida. The period of performance runs from September 1, 2026, through March 31, 2031. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $734.8k | 9/1/26 |