Project Grant R01HL181587
- This $740,338 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of Protease Activated Receptor 2 (PAR2) in the initiation and progression of abdominal aortic aneurysms (AAAs). The research aims to determine how PAR2 expression and activity in vascular smooth muscle cells may impact the structural integrity of the aortic wall and contribute to AAA...
- The University of Cincinnati, through its Sponsored Research Services Division, was awarded a $156,276 project grant by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on "Hematopoietic Cells and Chemokine Regulation in Abdominal Aortic Aneurysm Associated Thrombosis". The project, with a performance period from August 1, 2025 to June 30, 2027, aims to investigate the role of platelet activation and...
- This $169,560 Project Grant was awarded on March 1, 2025 by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the Regents of the University of Michigan. The grant supports research to elucidate the role of the PERK/EIF2A/ATF4 endoplasmic reticulum stress response and MLL1-mediated CHOP expression in vascular smooth muscle cell apoptosis, with the goal of identifying therapeutic targets to limit abdominal aortic aneurysm (AAA) expansion. The research...
- This federal Project Grant award of $686,685 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to study the genetic and epigenetic factors that influence the development of abdominal aortic aneurysms (AAA) related to tobacco use. The primary awardee, The Leland Stanford Junior University, will leverage its expertise in vascular biology and genetic research to develop an innovative mouse model of chronic tobacco-induced AAA. The...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,102,500 in funding to the University of California, Los Angeles (UCLA) from August 2025 through April 2032. The objective of the project is to address persistent problems in intravascular triglyceride metabolism, which can lead to higher levels of atherogenic lipoproteins and increased risk of coronary heart disease. The project builds on the awardee's prior...
- This Project Grant award, valued at $733,439.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Regents of the University of Michigan. The grant supports research to define the molecular triggers and consequences of CART signaling in aortic smooth muscle cells, and determine the role of sexually dimorphic signaling mechanisms in thoracic aortic aneurysm (TAA) pathogenesis. The research aims to advance the...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $410,139.00 to the University of Pittsburgh to advance the development of a novel density-driven strength assessment tool for predicting the risk of thoracic aortic aneurysm (TAA) rupture or dissection. The project aims to: Assess the relationship between TAA tissue density and local tissue strength, and Evaluate the use of diffusion tensor magnetic...
- This federal Project Grant award of $2,508,095, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Yale University to investigate the role of cell-extracellular matrix interactions in the development of thoracic aortic disease. The research aims to elucidate the underlying mechanisms driving thoracic aortopathy, such as aortic aneurysms, dissection, and rupture, in order to identify potential targets for...
- This federal Project Grant award of $174,389 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Dr. Nupoor Narula at Weill Medical College of Cornell University on the impact of aortic grafts on cardiovascular remodeling and outcomes in genetically triggered aortic aneurysms. The 5-year award, beginning September 5, 2025, will leverage advanced cardiac MRI techniques and rigorous genetic analyses to assess how the stiffness of...
- This federal Project Grant award of $240,000.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Baylor College of Medicine. The funding supports research aimed at elucidating the role of genetic variants associated with thoracic aortic aneurysms and dissections (TAAD) in driving epigenetic and regulatory changes that increase susceptibility to these life-threatening cardiovascular conditions. The research...
This $713,382 Project Grant award from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of Pennsylvania on the role of triglyceride-rich lipoproteins in the growth and progression of abdominal aortic aneurysms. The research aims to generate definitive causal evidence on how triglyceride-rich lipoproteins influence the development, growth, and rupture of these life-threatening aortic aneurysms, with the goal of advancing non-surgical therapies to prevent aortic rupture. The grant provides funding over a 4-year period from August 2025 to July 2029 to investigate the mechanistic links between triglyceride-rich lipoproteins and aortic aneurysm progression through a comprehensive research program at the University of Pennsylvania.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $713.4k | 8/8/25 |