Project Grant R21HL181658
- This Project Grant award of $715,180 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to understand the epigenetic regulation of trained immunity in thoracic aortic aneurysms and dissections. The objective is to determine how monocytes/macrophages in the aortic wall are trained to exhibit a pro-inflammatory phenotype, with the goal of identifying key pathways driving this process. The research will be conducted by Baylor...
- This federal Project Grant award of $2,508,095, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Yale University to investigate the role of cell-extracellular matrix interactions in the development of thoracic aortic disease. The research aims to elucidate the underlying mechanisms driving thoracic aortopathy, such as aortic aneurysms, dissection, and rupture, in order to identify potential targets for...
- This federal Project Grant award of $686,685 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to study the genetic and epigenetic factors that influence the development of abdominal aortic aneurysms (AAA) related to tobacco use. The primary awardee, The Leland Stanford Junior University, will leverage its expertise in vascular biology and genetic research to develop an innovative mouse model of chronic tobacco-induced AAA. The...
- This Project Grant award, valued at $733,439.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Regents of the University of Michigan. The grant supports research to define the molecular triggers and consequences of CART signaling in aortic smooth muscle cells, and determine the role of sexually dimorphic signaling mechanisms in thoracic aortic aneurysm (TAA) pathogenesis. The research aims to advance the...
- The federal Project Grant award of $535,556.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Alabama at Birmingham (UAB). The funding will support a research project to investigate the role of a novel histone modification, H3T32 O-GlcNAc, in endothelial cell dysfunction and atherosclerosis. The 5-year project aims to elucidate the epigenetic features of this histone modification under...
- This federal Project Grant award, valued at $752,618, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Baylor College of Medicine. The grant supports a research project focused on understanding the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery. The research aims to investigate the molecular drivers of POAF, including the involvement of infiltrating macrophages,...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $410,139.00 to the University of Pittsburgh to advance the development of a novel density-driven strength assessment tool for predicting the risk of thoracic aortic aneurysm (TAA) rupture or dissection. The project aims to: Assess the relationship between TAA tissue density and local tissue strength, and Evaluate the use of diffusion tensor magnetic...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $164,127 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Texas Health Science Center at Houston (UTHealth) to develop an artificial intelligence-based facial recognition tool for screening and early detection of heritable thoracic aortic disease (HTAD). The project aims to leverage facial image data from the Montalcino Aortic Consortium's patient registry to build a...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the mechanistic relationship between bicuspid aortic valve (BAV) structure, mechanical stress, and the development of premature calcific aortic stenosis. The $147,486 grant, awarded on September 5, 2025, will enable the Medical College of Wisconsin to conduct this research using mouse models of human disease integrated with in vitro...
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
This federal Project Grant award of $240,000.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Baylor College of Medicine. The funding supports research aimed at elucidating the role of genetic variants associated with thoracic aortic aneurysms and dissections (TAAD) in driving epigenetic and regulatory changes that increase susceptibility to these life-threatening cardiovascular conditions. The research integrates genome-wide association study data with single-cell chromatin accessibility analysis of human aortic tissues to identify how TAAD-associated genetic variants impact transcription factor binding and epigenetic modifications in key cell types, leading to dysregulation of extracellular matrix and inflammatory genes. The project runs from August 15, 2025 through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $240.0k | 8/8/25 |