Project Grant K99HL181189
- This $740,338 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of Protease Activated Receptor 2 (PAR2) in the initiation and progression of abdominal aortic aneurysms (AAAs). The research aims to determine how PAR2 expression and activity in vascular smooth muscle cells may impact the structural integrity of the aortic wall and contribute to AAA...
- The University of Cincinnati was awarded a $698,432 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on "Stress Regulated RNA Degradation in Cardiac Hypertrophy." The project aims to establish the role of the UPF1 RNA helicase and the RBFOX1C RNA binding protein in regulating mRNA degradation in response to cardiac stress, and to determine the functional significance of this stress-regulated mRNA...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $445,500 supports research to define the mechanisms by which platelets may regulate monocyte/macrophage interactions at the site of abdominal aortic aneurysm (AAA) injury, with the goal of developing new tools to promote tissue regeneration and healing of cardiovascular damaged tissues. The research aims to provide a blueprint for site-specific regeneration and healing of AAAs, which...
- This $713,382 Project Grant award from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of Pennsylvania on the role of triglyceride-rich lipoproteins in the growth and progression of abdominal aortic aneurysms. The research aims to generate definitive causal evidence on how triglyceride-rich lipoproteins influence the development, growth, and rupture of these life-threatening aortic aneurysms, with the goal...
- The University of Cincinnati received a $728,776 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) effective September 3, 2025 with a completion date of May 31, 2029. The grant supports research to investigate the role of sphingolipid metabolism and signaling in the lung disease lymphangioleiomyomatosis (LAM), which primarily affects young women. The research aims to elucidate the molecular mechanisms by which the TSC2 gene...
- This Project Grant award, valued at $733,439.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Regents of the University of Michigan. The grant supports research to define the molecular triggers and consequences of CART signaling in aortic smooth muscle cells, and determine the role of sexually dimorphic signaling mechanisms in thoracic aortic aneurysm (TAA) pathogenesis. The research aims to advance the...
- This federal Project Grant award of $2,508,095, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Yale University to investigate the role of cell-extracellular matrix interactions in the development of thoracic aortic disease. The research aims to elucidate the underlying mechanisms driving thoracic aortopathy, such as aortic aneurysms, dissection, and rupture, in order to identify potential targets for...
- This $169,560 Project Grant was awarded on March 1, 2025 by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the Regents of the University of Michigan. The grant supports research to elucidate the role of the PERK/EIF2A/ATF4 endoplasmic reticulum stress response and MLL1-mediated CHOP expression in vascular smooth muscle cell apoptosis, with the goal of identifying therapeutic targets to limit abdominal aortic aneurysm (AAA) expansion. The research...
- This $722,299 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research initiative to use deep learning techniques to study normal variation in aortic valve hemodynamics and its link to the development of aortic stenosis. The primary objectives are to: 1) Measure aortic valve parameters in 100,000 UK Biobank participants using deep learning models, validate the measurements at UCSF, and develop models to identify...
- This federal Project Grant award, totaling $756,875.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati. The award supports research to investigate the fundamental mechanisms by which neutrophil extracellular traps (NETs) contribute to airway damage and infection in mucoobstructive lung diseases, such as cystic fibrosis. Key research aims include examining how NET-mediated...
The University of Cincinnati, through its Sponsored Research Services Division, was awarded a $156,276 project grant by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on "Hematopoietic Cells and Chemokine Regulation in Abdominal Aortic Aneurysm Associated Thrombosis". The project, with a performance period from August 1, 2025 to June 30, 2027, aims to investigate the role of platelet activation and coagulation in the development of abdominal aortic aneurysms, which can lead to fatal aortic rupture. The research focuses on addressing sex as a biological variable, as women are disproportionately affected by aortic rupture. The project will leverage the university's expertise in cardiovascular research and build on preliminary data demonstrating increased platelet activation in abdominal aortic aneurysm patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.3k | 8/14/25 |