Project Grant R21HL181549
- This Project Grant award, valued at $733,439.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Regents of the University of Michigan. The grant supports research to define the molecular triggers and consequences of CART signaling in aortic smooth muscle cells, and determine the role of sexually dimorphic signaling mechanisms in thoracic aortic aneurysm (TAA) pathogenesis. The research aims to advance the...
- This $713,382 Project Grant award from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of Pennsylvania on the role of triglyceride-rich lipoproteins in the growth and progression of abdominal aortic aneurysms. The research aims to generate definitive causal evidence on how triglyceride-rich lipoproteins influence the development, growth, and rupture of these life-threatening aortic aneurysms, with the goal...
- This federal Project Grant award of $240,000.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Baylor College of Medicine. The funding supports research aimed at elucidating the role of genetic variants associated with thoracic aortic aneurysms and dissections (TAAD) in driving epigenetic and regulatory changes that increase susceptibility to these life-threatening cardiovascular conditions. The research...
- This $750,345 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Pittsburgh. The funding supports research to investigate the role of telomerase reverse transcriptase (TERT) in the osteogenic reprogramming of aortic valve interstitial cells, which can lead to calcific aortic valve disease. The project aims to elucidate the epigenetic and transcriptional changes directed by...
- This $726,205 federal Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and validation of a new super-resolution intravascular ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the coronary vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques to better assess plaque vulnerability and prevent acute coronary syndromes. The project involves creating an...
- This $740,338 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of Protease Activated Receptor 2 (PAR2) in the initiation and progression of abdominal aortic aneurysms (AAAs). The research aims to determine how PAR2 expression and activity in vascular smooth muscle cells may impact the structural integrity of the aortic wall and contribute to AAA...
- This federal Project Grant award of $2,508,095, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Yale University to investigate the role of cell-extracellular matrix interactions in the development of thoracic aortic disease. The research aims to elucidate the underlying mechanisms driving thoracic aortopathy, such as aortic aneurysms, dissection, and rupture, in order to identify potential targets for...
- This federal Project Grant award of $686,685 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to study the genetic and epigenetic factors that influence the development of abdominal aortic aneurysms (AAA) related to tobacco use. The primary awardee, The Leland Stanford Junior University, will leverage its expertise in vascular biology and genetic research to develop an innovative mouse model of chronic tobacco-induced AAA. The...
- The Regents of the University of Minnesota was awarded a $389,748 project grant from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a proof-of-concept study on using carotid pulse arrival time (CPAT) as a potential biomarker for monitoring ascending thoracic aortic aneurysm. The grant will fund experiments to determine if CPAT can reliably measure population-level trends in pulse wave velocity, as well as computer...
- This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Aneurisk, Inc. to develop and validate machine learning models for risk classification, growth projection, and wall stress prediction for abdominal aortic aneurysms (AAA). The project aims to create an artificial intelligence-based clinical decision support tool that enables clinicians to improve the treatment of patients with...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $410,139.00 to the University of Pittsburgh to advance the development of a novel density-driven strength assessment tool for predicting the risk of thoracic aortic aneurysm (TAA) rupture or dissection. The project aims to: This research seeks to enable more reliable, non-invasive assessment of TAA wall strength and stress to improve the prediction of catastrophic TAA failure, which can lead to death. The award period runs from August 10, 2025 to May 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $410.1k | 8/7/25 |