Project Grant R01HL179301
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $1.576 million Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective September 1, 2025, through May 31, 2030, to investigate the relationship between menopause-related vasomotor symptoms and cardiovascular disease (CVD) risk in midlife women. The research will prospectively study 120 peri- and post-menopausal women with cardiometabolic risk factors...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $252,000 project grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2027. This ancillary study investigates the relationship between menopausal hormone therapy, gut microbiome composition, and estrogen-related health outcomes in women living with HIV (WWH). The research leverages an...
- Grant Award Summary The University of California, San Francisco (UCSF) received a $198,549 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through November 30, 2030. This research project investigates the synergistic effects of menopause and Human Immunodeficiency Virus (HIV) on cardiovascular disease risk in women, addressing an emerging health priority given that over...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Oklahoma Health Sciences Center a $2,077,583 Project Grant effective September 25, 2025, through July 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This research grant supports investigation of estrogen signaling mechanisms in chronic asthma, with particular focus on how estrogen-metabolizing enzymes—specifically cytochrome P450 (CYP) enzymes and the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $722,937 to the University of Wisconsin-Madison on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a five-year project investigating sex-specific cerebrovascular dysfunction in metabolic syndrome. The research will deliver scientific insights into the mechanisms underlying reduced cerebral blood flow (CBF) in metabolic syndrome patients, with particular emphasis...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $429,000 to the University of Colorado-Denver through the Aging Research program (CFDA 93.866) on January 1, 2026, to support a two-year research project concluding December 31, 2027. This Project Grant funds biomedical research investigating the role of decreased estradiol in modulating crotonylation of myofilament proteins in aged female hearts. The research addresses the mechanisms underlying estradiol-mediated...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Regents of the University of Colorado (University of Colorado-Denver) a Project Grant totaling $163,145 under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 1, 2025, through August 31, 2030. This research project investigates sex differences in cardiac macrophages in response to pulmonary hypertension (PAH), a progressive and incurable disease with higher prevalence in...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Johns Hopkins University a Project Grant of $638,176 effective May 1, 2026, through February 28, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports basic research investigating thrombospondin-1 (TSP-1), a matricellular protein implicated in cardiac fibrosis associated with heart failure with preserved ejection fraction (HFpEF). The research will elucidate the...
- This $148,568 federal Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of inflammation and sex-specific differences in the progression of aortic valve stenosis (AVS). The key objectives are to: 1) delineate how secreted factors from valve cells impact macrophage phenotype and vice versa in a sex-dependent manner, and 2) elucidate sex-specific differences in AVS...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $249,000 Project Grant to The University of Texas Southwestern Medical Center on February 16, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports a three-year research initiative (completion date: January 31, 2029) led by Dr. Chengyi Tu to investigate the molecular mechanisms underlying tachycardia-induced cardiac dysfunction. The research leverages induced...
This project grant award of $656,212 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research investigating sex-specific cardiometabolic responses to hormone therapy. Awarded to Tulane University on April 17, 2026, with completion scheduled for March 31, 2030, the research will characterize how testosterone affects cardiovascular health in females and how estrogen affects cardiovascular health in males—areas with limited current understanding. The project will deliver scientific findings on vascular mechanisms underlying these hormone-specific responses, including the role of the G protein-coupled estrogen receptor (GPER) in protecting against arterial stiffening, an early indicator of vascular damage. The research will produce novel therapeutic strategies to optimize cardiometabolic health in patients undergoing hormone therapy by exploring co-treatment with a non-classical estrogen receptor agonist to preserve metabolic benefits while protecting the vasculature. Through pharmacological and genetic approaches in animal models, the project will generate new data characterizing the independent roles of estrogen and androgen signaling in vascular and metabolic outcomes, ultimately providing evidence-based guidance for safer hormone therapy management in both sexes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $656.2k | 4/27/26 |