Project Grant K08HL175217
- This federal Project Grant award for $111,626.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate macrophage populations and their role in pulmonary hypertension associated with sickle cell disease. The 2-year research project aims to determine if targeting iron release can modify CD169+ macrophages and adaptive immune cells, and if ablation of CD169+ macrophages can inhibit the progression of...
- This $117,000 Project Grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports secondary analysis of 3D echocardiographic (echo) images of the right ventricle (RV) to compute 3D surface strain. The goal is to develop enhanced 3D strain analysis techniques that can provide more detailed characterization of RV deformation compared to standard 2D global longitudinal strain (GLS) measures, with the potential to improve...
- This $193,896 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to identify clinical markers that can serve as surrogates for right ventricular-pulmonary artery (RV-PA) coupling, a metric that quantifies right ventricular adaptation in pulmonary arterial hypertension (PAH). The grantee, The Johns Hopkins University, will leverage a unique dataset of over 100 PAH patients to 1) develop a multivariable model...
- This $428,220 federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research by the University of Colorado-Denver to provide "Innovative Insights into Pulmonary Hypertension Progression: Unraveling the Role of Localized Small Extracellular Vesicles." The research, conducted from December 1, 2024 through November 30, 2026, aims to advance the scientific understanding of pulmonary hypertension and...
- This $761,615 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the role of biological sex in the heterogeneity of Acute Respiratory Distress Syndrome (ARDS). The research team at Massachusetts General Hospital aims to determine how increased alveolar epithelial expression of Secretory Leukocyte Protease Inhibitor (SLPI) in females may increase epithelial glycocalyx resilience, leading to a...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $245,626 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Johns Hopkins University. The grant, with a project period from February 1, 2025 to January 31, 2027, will fund research to validate lipidomic signatures associated with right ventricular and pulmonary vascular dysfunction in pulmonary arterial hypertension (PAH). The project aims to replicate the researchers' preliminary findings on...
- This $148,568 federal Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of inflammation and sex-specific differences in the progression of aortic valve stenosis (AVS). The key objectives are to: 1) delineate how secreted factors from valve cells impact macrophage phenotype and vice versa in a sex-dependent manner, and 2) elucidate sex-specific differences in AVS...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $586,637 to the University of New Mexico (UNM) to conduct research into the mechanisms of immune dysregulation that contribute to the development of hypoxic pulmonary hypertension (PH). The research aims to identify how chronic hypoxia causes a decrease in regulatory T cells (Tregs) and promotes the development of self-reactive T helper 17 (Th17) cells that target...
- This $275,196 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Chicago investigating the impact of adolescent reproductive health factors on the risk of cardiometabolic disease in young adult women. The project aims to analyze longitudinal data from the Pittsburgh Girls Study to examine associations between adolescent pubertal development, sexual health, and pregnancy history with...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,385,536 to Rhode Island Hospital to conduct research on pulmonary arterial hypertension (PAH). The goal is to characterize endothelial cell (EC) dysfunction in PAH, with a focus on understanding the role of anoikis resistance - abnormal programmed cell death triggered by cell detachment from the vessel wall. The research will leverage a "cell...
This federal Project Grant award of $163,145.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate sex differences in cardiac macrophages and their role in right ventricular function in pulmonary arterial hypertension (PAH). The University of Colorado-Denver, the awardee, will conduct this research with the goal of understanding how female sex hormones regulate gene expression in right ventricular macrophages and influence the fibrotic programming that contributes to maladaptive remodeling in PAH. This 5-year project, starting on September 1, 2025, aims to elucidate the mechanisms underlying the observed survival advantage in female PAH patients compared to males, which remains an important knowledge gap in cardiovascular research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $163.1k | 8/30/25 |