Project Grant R01HL178456
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pittsburgh a $688,163 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) beginning September 1, 2025, and concluding May 31, 2029. This research grant supports an investigator-initiated project examining indole metabolites as xenobiotic danger signals in acute lung injury. The principal investigator, a physician in pulmonary and critical care medicine at the...
- Federal Grant Award Summary The University of Pittsburgh received a $300,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for June 30, 2029. The project, titled "Real-Time Evaluation of Acute Myocardial Infarction with Multi-Lead ECG Monitoring from Wearable PPG Measurements," aims to develop and validate innovative diagnostic capabilities...
- Federal Project Grant Award Summary The University of Pittsburgh received a $1.39 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 20, 2025, with completion targeted for April 30, 2029. This award funds research investigating the mechanistic role of microbial-derived metabolites in obesity-associated asthma. The research will examine how gut dysbiosis—specifically dysregulated bile acid...
- Federal Grant Award Summary The University of Pittsburgh received a $258,516 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 15, 2025 through June 30, 2027. This award funds research investigating mitochondrial-derived peptides (MDPs) in chronic obstructive pulmonary disease (COPD), a condition affecting approximately 16 million U.S. adults and representing the sixth leading cause of death...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $706,519 Project Grant to the University of Pittsburgh under the Cardiovascular Diseases Research program (CFDA 93.837) on September 15, 2025, with completion expected by June 30, 2030. This award funds research investigating the non-canonical roles of NIPBL (Nipped-B-Like protein) in cardiomyocytes to address a critical knowledge gap in Cornelia de Lange Syndrome (CDLS) cardiac disease mechanisms. The...
- Federal Grant Award Summary The University of Pittsburgh received a $791,485 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2029. This award funds research on the treatment of post-infarction cardiac remodeling through the development and validation of ultrasound-targeted microbubble cavitation (UTMC), a theranostic ultrasound-based therapeutic approach. The...
- Federal Project Grant Award Summary The University of Pittsburgh received a $100,228 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on September 30, 2026, with a completion date of April 30, 2028. This research project, conducted at the University of Pittsburgh's Pittsburgh, Pennsylvania campus, focuses on elucidating the mechanisms that regulate regulatory T cell (Treg) tissue responses driven by...
- Federal Grant Award Summary The University of Pittsburgh received a $2.37 million Project Grant award dated May 1, 2026, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, which extends through February 29, 2028, funds research on manipulating leucine uptake, sensing, and metabolism in macrophages as diagnostic and therapeutic strategies for atherosclerosis. The project builds on a decade of prior work...
- Federal Grant Award Summary The University of Pittsburgh received a $1.36 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2025, with completion targeted for April 30, 2029. This research initiative develops minimally invasive treatment strategies for ischemic cardiomyopathy (ICM) through targeted injection of thermoresponsive hydrogels designed to interrupt progressive...
- Federal Project Grant Award Summary The University of Pittsburgh received a $1.42M Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with a completion date of May 31, 2029. This grant funds research investigating ALK1 (Activin Receptor-Like Kinase 1) ligand requirements for arteriovenous malformation (AVM) prevention in Hereditary Hemorrhagic Telangiectasia (HHT). The research...
The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pittsburgh a $701,449 Project Grant effective June 1, 2026, through April 30, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports basic and translational research investigating the role of peroxisome proliferator-activated receptor alpha (PPARA) activation in mediating sex-specific differences in doxorubicin-induced cardiotoxicity. The research will address a critical knowledge gap regarding why premenopausal women experience reduced cardiotoxic effects from the chemotherapy agent doxorubicin compared to age-matched men. The research deliverables encompass three primary aims: (1) testing PPARA activation and fatty acid metabolism in promoting sex-specific cardiotoxicity; (2) elucidating mechanistic pathways by which estrogen signaling regulates PPARA; and (3) validating cardioprotective therapeutic approaches using both tumor-bearing mice models and a novel human cardio-oncology organotypic platform. The core hypothesis posits that estrogen-mediated PPARA activation prevents fatty acid metabolic impairment and ameliorates doxorubicin cardiotoxicity. Preliminary findings demonstrate that PPARA genetic ablation abolishes sex differences and worsens cardiotoxicity, while pharmacological PPARA activation ameliorates cardiotoxic effects in human cardiac tissue, supporting the therapeutic potential of PPARA-targeted interventions for chemotherapy-induced cardiotoxicity prevention.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $701.4k | 6/1/26 |