Project Grant R01HL183153
- Federal Project Grant Award Summary The University of Pittsburgh received a $756,607 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion expected by April 30, 2033. This research initiative investigates lysosomal nutrient-sensing mechanisms in macrophages as a therapeutic approach to atherosclerosis and cardiovascular disease. The research leverages transcription factor EB...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Louisiana State University Health Sciences Center-Shreveport a Project Grant of $659,441 under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct basic science research investigating nutrient sensing mechanisms in macrophage-mediated clearance of apoptotic cells. The research, which commenced August 15, 2025, and extends through May 31, 2029, seeks to elucidate the molecular pathways...
- Federal Project Grant Award Summary Louisiana State University Health Sciences Center-Shreveport received a $737,242 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026, with completion targeted for January 31, 2030. The research project investigates macrophage one-carbon metabolism's role in atherosclerotic plaque stability, with the goal of identifying novel therapeutic targets to...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pittsburgh a $688,163 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) beginning September 1, 2025, and concluding May 31, 2029. This research grant supports an investigator-initiated project examining indole metabolites as xenobiotic danger signals in acute lung injury. The principal investigator, a physician in pulmonary and critical care medicine at the...
- Federal Project Grant Award Summary The University of Pittsburgh received a $1,392,946 Project Grant awarded July 20, 2025, by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on obesity-associated asthma through completion April 30, 2029. This research project investigates the mechanistic relationship between gut dysbiosis, microbial-derived metabolites, and airway hyperresponsiveness in obese patients...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $167,400 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective September 1, 2025, through August 31, 2027, funds research investigating an athero-protective pathway mediated by macrophage tryptophan metabolism and aryl hydrocarbon receptor (AHR) activation. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Columbia University's Health Sciences Division a $1,151,500 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) to investigate novel concepts in macrophage biology and their roles in atherosclerotic cardiovascular disease and cardiometabolic disease. The award, obligated on March 9, 2026, with a completion date of February 28, 2033, supports a comprehensive research program examining the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded New York University's Long Island School of Medicine a Project Grant totaling $2,728,306 under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on reducing plasma cholesterol and atherosclerosis using microRNA-30C analog C2. The research initiative, which commenced on September 24, 2025, and extends through August 31, 2027, focuses on developing and validating a novel synthetic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Connecticut Health Center a $227,878 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective June 20, 2025, with completion targeted for January 31, 2028. This research initiative investigates the role of TRPM7 (Transient Receptor Potential Protein, Melastatin Family Member 7) in macrophage-mediated atherosclerosis development. The project will generate...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $706,519 Project Grant to the University of Pittsburgh effective September 15, 2025, through June 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This research initiative investigates the non-canonical roles of NIPBL (Nipped-B-Like protein) in cardiomyocytes to address a critical knowledge gap in understanding cardiac dysfunction in Cornelia de Lange Syndrome (CDLS)....
This Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports basic and translational research investigating the role of leucine metabolism in atherosclerosis development. The University of Pittsburgh received $788,863 in obligated funding for the project period from May 1, 2026, through February 28, 2030. The research will deliver scientific outputs focused on manipulating leucine uptake, sensing, and metabolism in macrophages through genetic and pharmacological approaches, with the objective of identifying both diagnostic and therapeutic strategies for atherosclerosis intervention. The project deliverables encompass three primary research aims designed to evaluate diagnostic and therapeutic potential by modulating macrophage leucine uptake, lysosomal nutrient-sensing mechanisms, and metabolic catabolism. Expected products include mechanistic discoveries regarding leucine-mTOR (mammalian target of rapamycin) signaling pathways in atherosclerotic plaques, characterization of the SLC7A5/LAT1 leucine transporter's role in disease progression, validation of leucine-based positron emission tomography (PET) imaging approaches for atherosclerotic plaque detection, and identification of pharmacological targets for therapeutic intervention. These research outputs are intended to advance fundamental understanding of amino acid nutrient-sensing in cardiovascular disease pathogenesis and provide novel diagnostic and treatment modalities to reduce atherosclerosis-related morbidity and mortality.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $788.9k | 5/4/26 |