This Project Grant award of $725,817 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of DNA methylation in the progression of chronic obstructive pulmonary disease (COPD). The key objectives are to develop novel computational methods for analyzing high-dimensional methylation data, identify methylation patterns linked to COPD outcomes, and compare epigenetic pathways between...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $762,867 to The Johns Hopkins University to conduct research on the role of the protein cofilin-1 in maintaining mitochondrial function and airway epithelial health. The research aims to 1) determine how the loss of cofilin-1 impacts mitochondrial dynamics, 2) assess the effects of cofilin-1 loss on mitophagy and mitochondrial...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $765,612.15 to the Research Institute at Nationwide Children's Hospital to conduct molecular analysis of airway secretory cells in the context of chronic obstructive pulmonary disease (COPD). The research aims to improve the understanding of cellular mechanisms underlying the small airway disease (SAD) and emphysema phenotypes of COPD,...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) at the National Institutes of Health will support research to determine the pathophysiological mechanism and potential therapeutic approaches for alleviating HIV-associated chronic obstructive pulmonary disease (COPD). The total award amount is $1,405,336 over the project period from September 1, 2024 to May 31, 2028. The primary focus is on investigating how HIV and...
This Project Grant award of $2,369,201, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to develop a population-based analytics and data infrastructure to evaluate the impact of non-COPD medications on outcomes for patients with Chronic Obstructive Pulmonary Disease (COPD). The overarching goal is to leverage existing claims data and electronic health records, including data from the COPDGene cohort study, to identify potential...
This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research will provide $131,783 to Brigham & Women's Hospital to conduct patient-oriented research and mentoring on COPD biomarker studies. The key objectives are to: 1) Develop and implement a protocol for collecting biospecimens before and after bronchoscopic lung volume reduction procedures to identify blood and fluid biomarkers associated with COPD exacerbations;...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $708,063 to the University of Virginia to conduct research on post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) develop a method to identify RNA-binding protein (RBP) to isoform regulatory networks in COPD, 2) functionally characterize COPD-associated RBP subnetworks, and 3) use long-read...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research (CFDA 93.837) federal grant program, aims to leverage quantitative imaging data from lung cancer screening to develop tools for detecting chronic obstructive pulmonary disease (COPD). The $626,247 award to the Regents of the University of Michigan will fund research to: 1) characterize COPD-related pathology from lung cancer screening CT scans, and 2) build a...
The University of Southern California (USC) Department of Contracts and Grants Division received a $413,958 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of this 1-year award, effective September 22, 2023, is to investigate the role of the protein PUMA in promoting cell death and inflammation in chronic obstructive pulmonary disease (COPD) caused by cigarette smoke exposure. The research aims...