This Project Grant award, valued at $730,392, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research conducted by the University of Colorado-Denver to investigate the role of adipose tissue and eosinophils in regulating airway function and inflammation in lean and obese mice. Specifically, the research aims to determine: 1) the metabolic response of adipose tissue to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $688,163 to the University of Pittsburgh to investigate the role of indole metabolites as danger signals that contribute to acute lung injury and the development of acute respiratory distress syndrome (ARDS). The research aims to: 1) determine the mechanism by which indole metabolites derived from microbes cause cell death in lung...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 - Cardiovascular Diseases Research, will provide $246,000.00 to the University of Chicago to investigate the immune cell landscape in Amish and Hutterite children and its relationship to asthma risk. The researchers will leverage the natural environmental differences between these two farming populations to generate multi-omic datasets characterizing the transcriptional and...
The National Heart, Lung, and Blood Institute (NHLBI), under CFDA 93.837 - Cardiovascular Diseases Research, awarded a $387,116 Project Grant to the University of South Florida. The 5-year grant, effective May 1, 2025, supports research to define the neural mechanisms by which house dust mite (HDM) exposure triggers airway hyperreactivity, a key characteristic of asthma. The research aims to identify the specific sensory nerve subtypes and signaling pathways activated by HDM that lead to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000 to Brigham & Women's Hospital Inc. to develop methodologies to reveal the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The project aims to create a strain-resolved computational pipeline for reduced metagenomic sequencing to profile the blood microbiome, and a deep-learning framework to...
This federal Project Grant award of $613,934 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research into the role of the aryl hydrocarbon receptor (AhR) signaling pathway in regulating airway smooth muscle responses during inflammation and asthma. The key objectives are to: 1) Determine the mechanisms of AhR expression and regulation in human airway smooth muscle under inflammatory conditions; 2) Investigate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $207,500 to the University of Southern California to study the role of the MIF/CD74 pathway in group 2 innate lymphoid cells (ILC2) and its impact on airway hyperreactivity and asthma. The key objectives of this 2-year research project are to: 1) Assess the expression patterns of CD74 in the lungs and measure...
This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $616,814 to the President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health, to conduct research on the role of microRNAs in regulating airway smooth muscle function and their contribution to asthma. The overarching goal is to establish the in vivo impact of key microRNAs in regulating airway smooth muscle proliferation,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $816,358 to Vanderbilt University Medical Center (VUMC) to conduct research on the effects of infant antibiotic exposure on the development of the early-life airway and gut microbiome, and the associated risk of childhood asthma. The goals of this 5-year project are to: 1) determine the age when infants are most susceptible to the harmful...