Project Grant R01HL175463

Award Date 5/15/25
Completion Date 2/28/29
Dollars Obligated $760K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Chapel Hill, NC 27599, USA
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The key objectives of this 4-year project are to: 1) Determine the transcriptomic changes that occur in neutrophils recruited to the lungs during S. pneumoniae pneumonia and assess the biological importance of these changes; and 2) Examine how the lung microenvironment evolves during the development and resolution of S. pneumoniae-induced inflammation and injury, and how this impacts neutrophil function. The research aims to provide novel insights into context-dependent neutrophil behavior and interactions within the lung during bacterial pneumonia, which could inform potential therapeutic strategies.

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