This $565,250 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a 5-year longitudinal study led by Duke University to characterize the effects of host-microbiome interactions on pulmonary function in a cohort of 500 adults with and without HIV in Botswana. The study will utilize advanced multi-omics techniques, including shotgun metagenomic sequencing, host...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,917,649 to the University of North Carolina at Chapel Hill to conduct research on HIV-associated lung disease. The project aims to characterize the nasal mucosal immune environment and microbiome of people living with HIV (PLWH) compared to seronegative individuals, and identify nasal mucosal endotypes associated with adverse pulmonary...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) will support $2,282,280 in research over the period from August 2024 to May 2028. The grant will fund investigations into the role of HIV-derived proteins, CD4+ T cells, and the protein podocan-like protein 1 (PODNL1) in the development of pulmonary vascular disease (PVD) among...
The University of Southern California (USC) Department of Contracts and Grants Division received a $413,958 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of this 1-year award, effective September 22, 2023, is to investigate the role of the protein PUMA in promoting cell death and inflammation in chronic obstructive pulmonary disease (COPD) caused by cigarette smoke exposure. The research aims...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $762,867 to The Johns Hopkins University to conduct research on the role of the protein cofilin-1 in maintaining mitochondrial function and airway epithelial health. The research aims to 1) determine how the loss of cofilin-1 impacts mitochondrial dynamics, 2) assess the effects of cofilin-1 loss on mitophagy and mitochondrial...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $258,516 to the University of Pittsburgh to investigate mitochondrial-derived peptides (MDPs) and their role in the development and progression of chronic obstructive pulmonary disease (COPD). The research aims to: 1) conduct a comprehensive analysis of MDPs and related genetic variations in human COPD samples, 2) define how these...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $765,612.15 to the Research Institute at Nationwide Children's Hospital to conduct molecular analysis of airway secretory cells in the context of chronic obstructive pulmonary disease (COPD). The research aims to improve the understanding of cellular mechanisms underlying the small airway disease (SAD) and emphysema phenotypes of COPD,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program will fund research to investigate the independent and interactive effects of obstructive sleep apnea (OSA) and HIV on ventricular repolarization abnormalities. The $115,125 grant will be awarded to the University of Miami's School of Medicine from February 1, 2025 to January 31, 2027. The research aims to delineate how OSA severity, nocturnal...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $708,063 to the University of Virginia to conduct research on post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) develop a method to identify RNA-binding protein (RBP) to isoform regulatory networks in COPD, 2) functionally characterize COPD-associated RBP subnetworks, and 3) use long-read...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $684,814 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the suppression of alveolar stem cells by tissue-resident lymphocytes in emphysema. The research aims to investigate how tissue factors in the lung alter the inflammatory response to viral infections, leading to the loss of alveolar type 2...