This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) totaling $1,602,792 provides funding to the University of North Carolina at Chapel Hill to investigate the phenotypic consequences of lipoprotein(a) in diverse global populations. The project aims to address key research gaps by assembling the largest and most ancestrally diverse consortium with validated lipoprotein(a) measures and genetic data. This will enable...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program for Cardiovascular Diseases Research (CFDA 93.837), provides $123,104 to Emory University to conduct research on factors contributing to cardiovascular disease (CVD) comorbidities in persons living with HIV (PWH). The key objectives are to: 1) assess relationships between the metabolome, lipidome, HIV reservoir, and subclinical CVD, analyzing differences by sex; and 2) determine...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) will support $2,282,280 in research over the period from August 2024 to May 2028. The grant will fund investigations into the role of HIV-derived proteins, CD4+ T cells, and the protein podocan-like protein 1 (PODNL1) in the development of pulmonary vascular disease (PVD) among...
This federal Project Grant award of $771,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to examine the effects of HIV-associated extracellular vesicles (EVs) containing the protein NEF on macrophage heterogeneity and function, and their contribution to the formation of high-risk atherosclerotic plaques in people living with HIV. The research aims to identify novel mechanisms and therapeutic targets related to impaired...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), is focused on understanding the mechanisms underlying HIV-associated hypertension and cardiovascular disease. The $641,960 award, granted to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), will fund research to investigate how HIV-derived proteins, specifically the Tat protein, contribute to the development of...
This Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $147,486 to Baylor College of Medicine to conduct research aimed at improving genetic testing for cardiovascular disease (CVD). The key objectives are to: Study the genetics of CVD and lipoprotein(a) (Lp(a)) across diverse and mixed-ancestry populations using novel tools that appropriately evaluate ancestry. This includes evaluating the role of linkage...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,917,649 to the University of North Carolina at Chapel Hill to conduct research on HIV-associated lung disease. The project aims to characterize the nasal mucosal immune environment and microbiome of people living with HIV (PLWH) compared to seronegative individuals, and identify nasal mucosal endotypes associated with adverse pulmonary...
This $1,102,500 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research at the University of California, Los Angeles (UCLA) to address persistent problems in the field of intravascular triglyceride metabolism. The key focus areas include: Identifying sequences in apolipoprotein A5 (apoA5) that are important for suppressing the activity of the ANGPTL3/8 complex, and using that knowledge...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $100,558 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to Stellenbosch University in South Africa. The grant, effective September 11, 2024 through August 31, 2029, will fund a series of prospective, multimodal cardiovascular research studies. The research aims to explore the underlying mechanisms of cardiovascular disease (CVD) in people living with HIV, characterize the impact of antiretroviral...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $198,549 to The Regents of the University of California, San Francisco to conduct research on the synergistic effects of menopause and HIV on cardiovascular disease risk in women. The key objectives are to: 1) Determine the association of HIV and menopausal phase with cardiovascular disease risk parameters; 2) Evaluate the association...