This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $708,063 to the University of Virginia to conduct research on post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The key objectives are to: Develop a method to identify RNA-binding protein (RBP) to isoform regulatory networks by integrating RBP binding assays and lung COPD transcriptomics...
This Project Grant award, valued at $131,783 and awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports a research study focused on identifying blood and lung fluid biomarkers for phenotypes and acute exacerbations of chronic obstructive pulmonary disease (COPD). The study protocol will enroll COPD patients undergoing bronchoscopic lung volume reduction procedures, as well as stable subjects with and without...
This $753,018 Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to examine the early life factors contributing to the development of airway dysanapsis, a mismatch between airway size and lung volume that is a major risk factor for chronic obstructive pulmonary disease (COPD). The primary research site is Columbia University, with a sub-award to Washington University to recruit...
This $675,739 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on the role of viral infections and autoantibodies in the progression of chronic obstructive pulmonary disease (COPD). The primary awardee, The Johns Hopkins University, will utilize blood samples from 3,000 COPD subjects in the COPDGene study to comprehensively assess for viral antibodies and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $151,578 to support research on skeletal muscle loss (sarcopenia) in patients with chronic obstructive pulmonary disease (COPD). The research aims to determine the role of hypoxia-inducible factor 1-alpha (HIF1A) in regulating skeletal muscle protein synthesis and homeostasis in response to prolonged intermittent hypoxia, a condition...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $203,974 to the University of Vermont & State Agricultural College to systematically assess the effects of normal and COPD-affected extracellular matrix (ECM) on the self-renewal and differentiation behaviors of airway basal epithelial cells (BCs) from both normal and COPD lungs. The researchers have developed novel...
This federal Project Grant award, with a total funding amount of $725,817, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports the "EPIGNOME: Epigenetic Graphical Networks of Methylation Effectors for COPD Progression" project, which aims to investigate the role of DNA methylation in the progression of chronic obstructive pulmonary disease (COPD). The project will...
This $807,434 Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) funds research to characterize alternative splicing related to chronic obstructive pulmonary disease (COPD) and cigarette smoke exposure in human airway epithelial cells. The key objectives are to: Generate genome-wide splicing QTL (sQTL) maps for primary human airway epithelial cells under cigarette smoke exposure and identify COPD-associated sQTLs. Perform fine...
This federal Project Grant award in the amount of $116,625.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), to The University of Iowa. The research study aims to characterize changes in airway and chest wall deformation between different lung volumes in patients with chronic obstructive pulmonary disease (COPD) and associated comorbidities. Specifically, the study will leverage established datasets from...
The federal Project Grant award, R00HL161446, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The $498,000.00 award supports research focused on "Molecular Analysis of Airway Secretory Cells in Health and Disease," with the ultimate goal of advancing the understanding of cellular mechanisms in chronic obstructive pulmonary disease (COPD), a leading cause of death. The research is being conducted...