This $807,434 Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) funds research to characterize alternative splicing related to chronic obstructive pulmonary disease (COPD) and cigarette smoke exposure in human airway epithelial cells. The key objectives are to: Generate genome-wide splicing QTL (sQTL) maps for primary human airway epithelial cells under cigarette smoke exposure and identify COPD-associated sQTLs. Perform fine...
This federal Project Grant award, with a total funding amount of $725,817, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports the "EPIGNOME: Epigenetic Graphical Networks of Methylation Effectors for COPD Progression" project, which aims to investigate the role of DNA methylation in the progression of chronic obstructive pulmonary disease (COPD). The project will...
This $675,739 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on the role of viral infections and autoantibodies in the progression of chronic obstructive pulmonary disease (COPD). The primary awardee, The Johns Hopkins University, will utilize blood samples from 3,000 COPD subjects in the COPDGene study to comprehensively assess for viral antibodies and...
This Project Grant award, valued at $131,783 and awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports a research study focused on identifying blood and lung fluid biomarkers for phenotypes and acute exacerbations of chronic obstructive pulmonary disease (COPD). The study protocol will enroll COPD patients undergoing bronchoscopic lung volume reduction procedures, as well as stable subjects with and without...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $572,076 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to Pennsylvania State University for the "Multi-Omic Characterization of COPD in Females" research project. This female-specific study aims to conduct genome-wide association studies, generate single-cell RNA sequencing data from female lung samples, and assemble a multi-ancestry plasma proteomics dataset to gain novel...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $762,867 to The Johns Hopkins University to investigate the role of the protein cofilin-1 in regulating mitochondrial function and repair mechanisms in airway epithelial cells. The research aims to determine how the loss of cofilin-1 impacts mitochondrial dynamics, mitophagy, and biogenesis, as well as its effects on airway epithelial...
This $753,018 Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to examine the early life factors contributing to the development of airway dysanapsis, a mismatch between airway size and lung volume that is a major risk factor for chronic obstructive pulmonary disease (COPD). The primary research site is Columbia University, with a sub-award to Washington University to recruit...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports research to better understand changes in the pulmonary vasculature and their relationship to lung disease in patients with pulmonary hypertension and chronic obstructive pulmonary disease (COPD). The $812,189 award, effective May 1, 2025 through February 28, 2029, will leverage data from several NIH-funded cohorts, including...
The federal Project Grant award, R00HL161446, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The $498,000.00 award supports research focused on "Molecular Analysis of Airway Secretory Cells in Health and Disease," with the ultimate goal of advancing the understanding of cellular mechanisms in chronic obstructive pulmonary disease (COPD), a leading cause of death. The research is being conducted...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $798,727 Cooperative Agreement under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of the University of Pennsylvania to research chronic lung diseases (CLDs) such as chronic obstructive pulmonary disease (COPD) and rare diseases like alpha-1 antitrypsin deficiency. The key objectives are to: Catalog the phenotypes of adult human lung diseases at the spatial and single-cell level, Identify molecular...