This federal Project Grant award of $2,282,280 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of HIV-encoded proteins in the development of pulmonary vascular disease (PVD) in people living with HIV. The research aims to identify new therapeutic targets for preventing HIV-associated PVD. Key activities include testing whether HIV proteins, such as Tat, contribute to PVD...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), provides $123,104 to Emory University to conduct research on the relationships between HIV reservoir size, the metabolome, lipidome, and subclinical cardiovascular disease (CVD) in persons living with HIV, with a focus on sex differences. The project will leverage Emory's expertise in high-resolution metabolomics, lipidomics, HIV persistence, and T cell...
This federal Project Grant award in the amount of $1,485,606.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports comprehensive research to understand the heightened risk of atherosclerotic cardiovascular disease (ASCVD) experienced by people living with HIV. The research aims to identify lipoprotein(a) (Lp(a)) risk thresholds, explore mechanisms linking Lp(a) to increased ASCVD risk, and...
This federal Project Grant award of $1,405,336.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to understand the pathophysiological mechanisms and potential treatments for HIV-associated chronic obstructive pulmonary disease (COPD). The primary awardee, Florida International University (FIU), will conduct in vitro and in vivo experiments to investigate how HIV Tat protein and cigarette smoke exposure...
This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support a series of prospective, multimodal cardiovascular research studies focused on exploring the underlying mechanisms of cardiovascular disease (CVD) in people living with HIV (PLWH) in South Africa. The $100,558 award, effective September 11, 2024 through August 31, 2029, will enable researchers at Stellenbosch University's...
This $1,251,718 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund a 5-year longitudinal study examining the cardiovascular and pulmonary outcomes of individuals with and without HIV after completion of tuberculosis (TB) treatment in Uganda. The primary objectives are to determine the prevalence, trajectory, and underlying mechanisms of cardiopulmonary abnormalities following TB, and to...
This $249,000 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research to investigate mechanisms that enhance and suppress HIV-1 resistance in gene-edited primary human cells. The goal is to develop a therapy for HIV using genetically modified autologous hematopoietic stem and progenitor cells. The research involves editing...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to externally validate and refine an agent-based model that simulates the effects of implementation strategies on improving hypertension care guidelines for persons with HIV in Indiana. The total funding amount for this 2-year project is $118,875, with an award date of September 1, 2024. The key objectives are to: 1) externally...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $115,125 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to the University of Miami. The grant will fund a 2-year research project to investigate the impact of obstructive sleep apnea (OSA) and HIV on ventricular repolarization lability, a risk factor for sudden cardiac death. The project aims to delineate the independent and interactive effects of OSA severity and HIV status on...
This $766,920 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to determine the mechanisms linking improvements in skeletal muscle metabolism with vascular health in obesity. The research will utilize novel tools to manipulate gene expression in lean and obese mice to unravel the integrated pathways that undermine cardiovascular function in obesity. Key focus areas include investigating the role...