This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will provide $706,220 to the University of Illinois to conduct research on the role of nuclear pore components in vascular function. The key focus is investigating how phosphorylation of the nucleoporin NUP93 regulates the subcellular localization of the transcriptional regulator YAP, and the impact on endothelial inflammation and atherosclerosis. The research plan...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $167,400 to Brigham & Women's Hospital to investigate how the immune mediator CD70 regulates endothelial function and metabolism, with the goal of identifying novel therapeutic targets for atherosclerotic cardiovascular disease. The 5-year award, beginning March 1, 2025, supports research to elucidate: 1) CD70 regulation of endothelial nitric oxide synthase;...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $787,267 to Yale University to conduct research on the role of cholesterol biosynthetic intermediates and derivatives in regulating macrophage function and inflammation in atherosclerosis. The research aims to determine whether genetic deletion of the DHCR24 enzyme in macrophages or hepatocytes can attenuate atherosclerosis progression by increasing desmosterol levels...
This $686,458 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a collaborative research effort between multiple institutions, led by Yale University, to develop a quantitative, predictive model of vascular remodeling in health and disease. The key products and services to be delivered through this grant include: Characterizing the roles of vascular endothelial...
This Project Grant award of $1,245,515.38 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at The Methodist Hospital Research Institute (HMRI) to study the relationship between cell metabolism and epigenetic regulation in transdifferentiation and vascular regeneration. The key objectives are to: Determine the molecular metabolic pathway that leads to the transdifferentiation of fibroblasts into endothelial cells, which can...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $641,816 to Rutgers, The State University of New Jersey to conduct research on the role of connexin hemichannels in the endothelium of resistance arteries. The objective is to identify the mechanisms by which the TRPV4 protein activates endothelial CX43 hemichannels, which is a critical step in triggering calcium increases and promoting endothelial...
The National Institutes of Health National Heart Lung and Blood Institute awarded a $511,680 Project Grant to the University of Illinois under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will fund research from February 2021 through August 2021 to investigate mechanisms by which vascular endothelial cells instruct macrophage fate in inflammatory injury. Specifically, the research will examine how endothelial cell Wnt signaling licenses the differentiation of monocytes...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $684,794 to the University of California, Merced to conduct research on the role of the blood vascular system and endothelial cells in the regeneration of the thymus after cytotoxic treatments. The key objectives are to utilize novel intravital imaging and oxygen microscopy techniques to (1) characterize the native thymic vascular...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA Program 93.837 Cardiovascular Diseases Research) provides $808,121 to the University of Southern California to elucidate how lymphatic endothelial cells detect external fluid forces and convert these signals into a biological program that orchestrates lymphatic valve formation. The research aims to understand the role of the mechanosensitive ion channel PIEZO1 in sensing fluid flow and activating downstream effectors...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,508,095 to Yale University to conduct research on the underlying mechanisms of thoracic aortopathy, which includes aortic aneurysms, dissection, and rupture. The overarching goal is to elucidate how aberrant interactions between vascular cells and the extracellular matrix lead to the deterioration of the thoracic aorta's biomechanical integrity, with the aim of...