This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support a research project at Yale University to develop a quantitative, predictive model of vascular remodeling in health and disease. The $686,458 award, effective July 10, 2024 through May 31, 2028, will enable the researchers to acquire quantitative data on interactions within vascular remodeling regulatory networks and develop a computational model of vascular remodeling. The model will be tested both in vitro and in vivo, with the goal of elucidating the regulatory networks governing vascular remodeling and identifying potential therapeutic targets for improving vascular insufficiency in coronary, peripheral, and cerebral artery disease. Yale University may also serve as a sub-awardee, providing expertise such as statistical analysis, clinical trial support, and lab testing services, to support related cardiovascular research projects.
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