Project Grant R01HL179007

Award Date 5/15/25
Completion Date 2/28/29
Dollars Obligated $808K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90033, USA
Similar Awards
This $587,042 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of store-operated calcium entry (SOCE) signaling in regulating the function of lymphatic muscle cells (LMCs). The research aims to: Assess the formation of SR-PM junctions and SOCE activity in LMCs. Determine the contribution of SOCE to pressure-dependent LMC pacemaking and contractility....
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, provides $116,278 to the University of South Florida to investigate the role of the plasminogen activator (PA) pathway in regulating lymphatic valve defects associated with lymphatic malformations. The researchers will assess the expression of key PA enzymes and utilize in vitro zymography to evaluate matrix metalloproteinase (MMP) activation,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to investigate the effectiveness and mechanisms of lymphaticovenous anastomoses (LVA) for treating lymphedema. The $144,362 award to Georgia Tech Research Corporation will utilize computational modeling, in vivo experiments, and analysis of clinical LVA data to gain deeper insights into lymphatic flow regulation and...
The federal Project Grant award R01HL171997, "PANX1-PIEZO1 INTERACTIONS REGULATE RENIN RELEASE", is funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837). The $717,773 grant supports research at the University of Virginia to investigate a novel mechanically-sensitive signaling axis involving PANX1 and PIEZO1 channels in juxtaglomerular cells, and how they may regulate renin release, a key process in the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $170,543 to Virginia Commonwealth University (VCU) for a 2-year period from September 1, 2024 to August 31, 2026. The funding supports research to characterize the mechanism by which the mechanoreceptor PIEZO2 drives metabolic adaptations in response to increased lung matrix stiffness, and how these metabolic changes contribute to...
This $329,551 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate how lipids regulate the activity of the PIEZO2 ion channel. The research aims to: Identify the molecular determinants of how phosphatidic acid (PA) and lysophosphatidic acid (LPA) inhibit PIEZO2 channels, but not PIEZO1 channels. Investigate the roles of PA and LPA in regulating PIEZO2 activity...
This federal Project Grant award, totaling $2,218,392.00, was issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award supports a comprehensive research project aimed at investigating the role of lymphatic system dysfunction in the pathogenesis of cerebral small vessel disease (CSVD) in the context of chronic hypertension. Key objectives of the project include: 1) determining the impact of...
This federal Project Grant award, totaling $108,405.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant is supporting research to determine if endothelial cell primary cilia respond to changes in hemodynamic forces during vascular development, define the mechanism by which primary cilia regulate vascular stabilization and mural cell function, and model novel cilia-related human congenital heart...
This Project Grant award, with a total funding amount of $265,151.00, was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the University of Southern California. The project aims to use mathematical modeling and experiments to understand what regulates leakiness in the lymphatic system, with the goal of developing strategies to modulate lymphatic permeability. The research will investigate how lipids regulate CD36, a long-chain fatty acid translocase,...
This Project Grant award in the amount of $508,436 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to investigate the "two-hit" model for the development of lymphatic malformations, a rare and complex disease with variable clinical manifestations. The research aims to determine whether VEGF-C, a lymphangiogenic growth factor, renders lymphatic vessels sensitive to the...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to elucidate the role of the mechanosensitive ion channel Piezo1 in lymphatic valve formation. The $808,121 award, valid from May 15, 2025 to February 28, 2029, will fund research at the University of Southern California to investigate how Piezo1 senses fluid flow and activates the transcription factor Prox1 to orchestrate lymphatic valve development. The project will incorporate in vitro experiments, ex vivo assays, and innovative animal models to understand the molecular mechanisms underlying this process. The findings could provide insights into the causes of lymphatic anomalies and identify new therapeutic targets for treating lymphatic-related disorders.

Generated 6/17/25, 4:29 AM