This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), will provide $1,092,000.00 to The Medical College of Wisconsin, Inc. over a 7-year period from May 1, 2025 to April 30, 2032. The award supports research to elucidate the molecular and physiological mechanisms controlling vasomotor function, arterial stiffness, and blood pressure regulation at the intersection of the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $161,948 to the University of Vermont & State Agricultural College to conduct research on the regulation of blood flow in the brain by capillary ATP-sensitive potassium (KATP) channels. The key research objectives are to: 1) elucidate the mechanisms by which capillary KATP channels increase cerebral blood flow in response to...
The federal Project Grant award R01HL171997, "PANX1-PIEZO1 INTERACTIONS REGULATE RENIN RELEASE", is funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837). The $717,773 grant supports research at the University of Virginia to investigate a novel mechanically-sensitive signaling axis involving PANX1 and PIEZO1 channels in juxtaglomerular cells, and how they may regulate renin release, a key process in the...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports comprehensive research on the molecular mechanisms by which the protein progranulin (PGRN) regulates endothelial cell function and blood pressure control. The $1,568,003 award, with a performance period from Sep 3, 2024 to Apr 30, 2029, aims to determine if reduced endothelial PGRN levels contribute to the development and progression of hypertension through...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $644,687 to the University of Missouri System to investigate a neural circuit involved in the peripheral chemoreflex and its contribution to hypertension following chronic intermittent hypoxia (CIH). The overarching goal is to use an integrative research approach, including chemogenetic and in vitro techniques, to resolve how an...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $786,060 to Vanderbilt University Medical Center (VUMC) from May 1, 2025 through March 31, 2029 to conduct research on the role of hypertension-induced trained immunity in myeloid cells as a determinant of atherosclerosis. The research aims to: 1) Determine how hypertension rewires the epigenome of myeloid progenitors to promote a...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $680,831 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Connecticut Health Center to conduct research on calcium signaling mechanisms in cardiac fibrogenesis. The goal is to investigate whether the channel function or kinase function of the TRPM7 protein is the key therapeutic target for mitigating cardiac fibrosis, a hallmark of heart disease. The project will apply multidisciplinary...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $620,371 to investigate the structure-function relationship of cardiac ion channels and their role in disease mechanisms. The research aims to characterize the conformational dynamics and voltage-sensing mechanisms of hyperpolarization-activated cyclic nucleotide-gated (HCN) and depolarization-activated KCNH potassium channels, which...
This federal Project Grant award for $2,395,029.00 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the role of endothelial cell metabolism and cell cycle regulation in mediating the effects of fluid shear stress on vascular health and atherosclerosis risk. The research aims to conduct a thorough unbiased analysis of the differential effects of laminar versus disturbed blood flow on endothelial cell...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $522,794 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Illinois to investigate the role of the voltage-gated proton channel HV1 in the development of pulmonary hypertension. The grant aims to elucidate the molecular mechanisms by which HV1 regulates the progression of pulmonary hypertension and explore the potential of HV1 blockers as a treatment approach. The project will utilize transgenic...