The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $802,500 Cooperative Agreement grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports the construction of a multi-scale 3D AI-powered map of genetic factors and cellular interactions driving normal and aberrant lung development in childhood interstitial lung disease (CHILD). The project will leverage single-cell and spatial...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $123,000 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Chicago to investigate the role of the Hedgehog (HH) signaling pathway in regulating progenitor cell differentiation during lung development and disease. The 2-year grant, which runs from February 2025 to November 2026, aims to: 1) decipher HH's temporal control over differentiation in mouse lungs, 2) characterize HH-receiving cell...
The federal Project Grant award R03HD113887, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of the ZFHX4 gene in lung mesenchyme development and its potential implications for understanding the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia (CDH). The $164,990 award, with a performance period from August 1, 2024 to...
This federal Project Grant award in the amount of $757,089 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to identify novel genes and genetic variants associated with congenital diaphragmatic hernia (CDH) and validate their role in mouse models. The awardee, Jackson Laboratory, will use genome data from a large CDH patient cohort to prioritize candidate genes and variants for validation in...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $740,317 to The Washington University in St. Louis to conduct research on the regulation of alveologenesis, the final phase of lung development, by FGF signaling pathways. The research aims to identify the cellular mechanisms by which FGF signaling regulates cell proliferation, differentiation, and death during the first and second stages...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $167,940 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) with a project period from Sep 20, 2024 to Aug 31, 2029. The grant aims to develop a novel mouse model of flow-induced pulmonary hypertension (PH) that better represents the physiological conditions observed in patients with congenital heart disease. Additionally, the project...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $844,386 to support research on the genetic landscape of childhood interstitial and diffuse lung diseases (CHILD). The key objectives are to: 1) Define molecular profiles of 300 CHILD lung biopsy samples to identify patient clusters with similar underlying causes, 2) Analyze whole exome sequence data from 400 children with...
The National Institute of Child Health and Human Development (NICHD) awarded The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), a $167,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to study the impact of epigenetic regulation on lung stem cells in congenital lung diseases. The project aims to determine how genetic variants and pharmaceutical interventions affect the differentiation and self-renewal of...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $773,916 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Children's Hospital Medical Center in Cincinnati, Ohio. The 5-year grant, which runs from August 2024 to June 2029, aims to create and validate a tool to calculate the contribution of each phenotype of bronchopulmonary dysplasia (BPD) to elevated breathing effort, known as the work of breathing (WOB), in premature neonates. The research...
The University of California, San Diego (UCSD) has been awarded a Cooperative Agreement from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The $747,861 award, effective September 1, 2024 through August 31, 2029, will fund a project titled "Cross-Disease Multi-Modality Mapping of the Human Lung". The research aims to leverage UCSD's expertise in lung biology and single-cell technologies to conduct direct...