The University of Chicago received a $123,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a computational research project titled "Hedgehog Signaling as a Regulator of Progenitor Differentiation for Organ Maintenance and Disease." This project aims to decipher the role of the Hedgehog signaling pathway in regulating the timing of lung cell differentiation during development and its potential contribution to chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). The researchers will analyze existing single-cell data from mouse and human lungs to understand how altered Hedgehog signaling impacts differentiation in both loss-of-function and gain-of-function scenarios. The project also seeks to identify disease-specific Hedgehog target genes that could lead to new therapeutic strategies. The award period is from February 1, 2025, to November 30, 2026.
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