Project Grant R03HD113887
- This federal Project Grant award of $123,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the Hedgehog signaling pathway in regulating progenitor cell differentiation during lung development and its potential contribution to lung diseases like COPD and IPF. The project will analyze existing single-cell data from mouse and human lungs to: 1) decipher the temporal control of Hedgehog signaling in regulating...
- This $161,500 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant is intended to establish basic science-clinical collaborations to understand the molecular mechanisms of heterotaxy, a severe form of congenital heart disease that affects 3-4% of patients with congenital heart defects. The funding will support research at the University of Virginia to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $629,498 to The Trustees of the University of Pennsylvania (UEI GM1XX56LEP58) to conduct research aimed at deciphering the molecular mechanisms underlying pediatric interstitial lung disease (CHILD). The key objectives are to: Interrogate the anomalous development of the lung epithelium in CHILD by defining the impact of a specific SFTPC gene mutation on alveolar...
- This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the mechanism of pluripotency transitions during peri-implantation development. The $760,617 award to The Children's Hospital Corporation, doing business as Boston Children's Hospital, aims to address the technical challenges in working with limited...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $594,583 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia (CHOP) Research Institute. The grant supports research to investigate the mechanisms regulating the development, expansion, and decline of neonatal lung myofibroblasts and their role in alveologenesis. Key objectives include utilizing a novel murine model to study myofibroblast lineage, characterize...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $339,000.00 to New York University (NYU) School of Medicine to conduct research on the genetic factors underlying Hirschsprung disease, a rare developmental disorder. The research aims to comprehensively characterize the genetic basis of Hirschsprung disease by analyzing whole genome sequencing data...
- This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the role of the hedgehog pathway and primary cilia axis in human lung alveologenesis and diseases such as bronchopulmonary dysplasia (BPD). The $156,168 grant awarded to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center will fund a 2-year study examining the cellular and molecular...
- This federal Project Grant award of $777,016.00 from the National Heart Lung and Blood Institute (CFDA Program 93.837 - Cardiovascular Diseases Research) supports research to functionally characterize genes and genetic variants associated with hypoplastic heart syndrome (HHS) in the Drosophila model organism. The University of Maryland, Baltimore is the primary awardee and will apply a high-throughput "gene replacement" approach to validate 386 genetic variants linked to HHS,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $267,000.00 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) for a project titled "Multimodal Characterization of Cardiac-Neurodevelopmental Genes." The project aims to (1) identify mechanisms by which certain genetic syndromes lead to alterations in both heart and brain development,...
- This $721,826 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify molecular mechanisms regulating alveolar matrix fibroblast function and their role in supporting vascular capillary formation. The research is being conducted by Children's Hospital Medical Center in Cincinnati, Ohio to advance the understanding of alveolar septation and septal wall maturation, which is...
The federal Project Grant award R03HD113887, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of the ZFHX4 gene in lung mesenchyme development and its potential implications for understanding the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia (CDH). The $164,990 award, with a performance period from August 1, 2024 to July 31, 2026, will fund two pilot assays to be conducted by the awardee, The General Hospital Corporation (doing business as Massachusetts General Hospital). The first assay will examine the dynamics of ZFHX4 binding, chromatin opening, and gene regulation in lung mesenchymal progenitors, while the second assay will identify ZFHX4-binding transcriptional regulators in these progenitor cells. The results of these studies are expected to inform our understanding of lung mesenchyme development and the pathogenesis of lung hypoplasia in CDH.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $165.0k | 7/30/24 |