A mechanistic 3D AI-powered map of genetic child
Active Cooperative Agreement Awarded Last action
- Award ID
- U01HL175383
- Recipient
-
Childrens Hospital Medical Center UEI JZD1HLM2ZU83
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,391,450
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date 43% complete
- Place of performance
- Cincinnati, OH 45229, USA
Award details come from USAspending.gov.
Description
- Abstract
- /summary leveraging the technologies and infrastructure in our previous lungmap phases, we will construct a multi-scale map of developing acinar and alveolar structures during normal childhood and in the setting of childhood interstitial lung disease (child) characterized by aberrant lung morphogenesis. Linked to gene variants, child provides a unique opportunity to understand key genetic pathways and cellular interactions of human acinar and alveolar development, in turn informing injury-repair associated with lung diseases throughout the lifespan. Working in a collaborative LUNGMAP3 consortium, including other research centers, the data coordinating center (DCC), the human tissue core (HTC), our LUNGMAP3 project will use single-cell and spatial multiomics, high-resolution confocal and electron microscopy, patient-derived ipscs, and bioinformatics including AI tools to define, model, and predict normal and diseased lung development. The resulting mechanistic insights and enabling technologies will be disseminated to the entire lung community via disease atlases and web portals, as we have done during LUNGMAP1 and 2, to accelerate lung biology discoveries and disease therapies.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $786,450 | |
| Amendment | $802,500 | |
| Original award | $802,500 |
Quick answers
Who received award U01HL175383?
U01HL175383 was awarded to Childrens Hospital Medical Center by National Heart Lung and Blood Institute (National Institutes of Health) on September 1, 2024.
How much is award U01HL175383 worth?
$2,391,450 has been obligated on U01HL175383.
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