Project Grant R01HL168663

Award Date 7/16/24
Completion Date 4/30/28
Dollars Obligated $2M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Baltimore, MD 21218, USA
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Specifically, the research team will utilize advanced phage immunoprecipitation sequencing (PhIP-seq) technology to comprehensively assess blood samples from 3,000 well-characterized COPD subjects for autoantibodies and antibodies indicative of prior viral infections. The project has three main objectives: 1) Assess associations between viral antibodies and longitudinal lung function decline, 2) Examine the relationship between autoantibodies and COPD status, lung function decline, and emphysema, and 3) Investigate how adaptive immunity and chronic inflammation pathways are linked to viral exposures and autoantibodies. This research will complement the existing clinical, genetic, and transcriptomic data from the COPDGene study to provide new insights into the role of the immune system in COPD progression.

The grant award includes a sub-award to Brigham & Women's Hospital, which will be responsible for processing plasma samples and collaborating on the integrative data analysis.

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