This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA Program 93.837 - Cardiovascular Diseases Research will provide $116,625 to The University of Iowa to characterize clinically relevant phenotypes related to osteoporosis and sarcopenia in chronic obstructive pulmonary disease (COPD). The project aims to develop normative models of phenotypic aging, automated CT-based measures of bone, muscle, and lung diaphragmatic surface deformation, and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research (CFDA 93.837) federal grant program, aims to leverage quantitative imaging data from lung cancer screening to develop tools for detecting chronic obstructive pulmonary disease (COPD). The $626,247 award to the Regents of the University of Michigan will fund research to: 1) characterize COPD-related pathology from lung cancer screening CT scans, and 2) build a...
This federal Project Grant award of $725,088 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to optimize the effectiveness and implementation of COPD self-management treatment. The primary goal is to conduct a factorial optimization trial among 448 individuals with COPD to evaluate the impacts of treatment components including self-management education, physical activity, and inhaler training on respiratory-related hospitalizations and...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $708,063 to the University of Virginia to conduct research on post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) develop a method to identify RNA-binding protein (RBP) to isoform regulatory networks in COPD, 2) functionally characterize COPD-associated RBP subnetworks, and 3) use long-read...
This $203,974 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a research project to investigate the effects of normal and diseased extracellular matrix (ECM) on the self-renewal and differentiation of airway basal epithelial cells. The project leverages novel tools developed by the co-PIs, including "inside-out" airway organoids and ECM hydrogels derived from normal and...
This Project Grant award of $2,369,201, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to develop a population-based analytics and data infrastructure to evaluate the impact of non-COPD medications on outcomes for patients with Chronic Obstructive Pulmonary Disease (COPD). The overarching goal is to leverage existing claims data and electronic health records, including data from the COPDGene cohort study, to identify potential...
This Project Grant award, with a funding amount of $551,863.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research to define the mechanism by which prostaglandin E2 (PGE2) balances the absorption and secretion of airway surface liquid by regulating ionocytes and secretory cells in the airway epithelium. The research aims to establish new regulatory nodes between ion transport, its...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $477,290 to Mayo Clinic to investigate the underlying behavioral mechanisms that impact a home-based pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The research aims to determine the associations between patterns of physical activity, sedentary behavior, sleep, and cognitive...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,107,276 to Lasarrus Clinic And Research Center Inc. to develop a mobile health system for remote monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD). The project aims to enhance patient adherence to remote monitoring and early symptom recognition, in order to reduce COPD readmissions and healthcare costs. The system utilizes a wearable...
This Project Grant award of $248,999 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support research at the University of Iowa to investigate mesenchymal cell plasticity and signaling in lung regeneration. The goal is to develop a comprehensive understanding of the progenitor cells and their functions after severe lung injury, as well as how they signal and interact with other cells within the injured alveolar niche. The research aims...