Project Grant R01HD121559
- Federal Project Grant Award Summary Yale University received a $100,228 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective December 1, 2026, with completion targeted for June 30, 2029. The award funds fundamental research into tubulin post-translational modifications (PTMs) in female meiosis, addressing a significant gap in reproductive biology. The project...
- Federal Grant Award Summary Yale University received a $132,022 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded July 1, 2026, with completion targeted for June 30, 2028. The research investigates the role of histone H4 acetylation (H4AC), specifically H4K12AC, in mammalian embryogenesis and its relationship to maternal aging-related fertility decline. The...
- Federal Grant Award Summary Yale University received a $1.85 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 15, 2025, with completion expected by April 30, 2030. The award supports fundamental research into mechanisms regulating chromatin organization and epigenetic memory during early vertebrate development. The research investigates how the...
- Federal Project Grant Award Summary Yale University received a $456,999 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026 through June 30, 2028. The award supports exploratory research investigating the role of acetyl-methyllysine (KAcMe) in spermatogenic development. The research addresses a gap in understanding histone modifications during...
- Federal Project Grant Award Summary Yale University received a $158,766 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through March 31, 2029. The award funds research to dissect the molecular mechanisms underlying endometriosis-related implantation defects and pregnancy complications through investigation of microRNA (miRNA) roles in...
- Federal Grant Award Summary Yale University received a $1.28 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion expected April 30, 2030. The project investigates the role of decidual extracellular vesicles (EVs) in mediating placental insufficiency, a pathological condition affecting 3–8% of pregnancies worldwide and...
- Federal Grant Award Summary Yale University received a $2.25 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 8, 2025, with completion targeted for April 30, 2030. The research focuses on advancing understanding of the genetic, cellular, and molecular mechanisms underlying reduced sperm motility in male infertility. The project leverages Yale's...
- Federal Project Grant Award Summary Princeton University received a $1.37 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded on August 9, 2025, with a completion date of April 30, 2030. The award funds research into the mechanisms of female germline cyst formation and oocyte selection in mice. The research will develop novel genetically encoded...
- Federal Project Grant Award Summary Yale University received a $1.93 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 25, 2025, with completion targeted for April 30, 2030. The award funds research investigating platelet dysfunction in pediatric multiple organ dysfunction syndrome (MODS), with specific focus on the role of endoplasmic reticulum...
- Federal Grant Award Summary Yale University received a $537,696 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through February 28, 2031. The award supports fundamental research investigating the coordination of germline chromatin organization mechanisms that initiate embryogenesis in the model organism Caenorhabditis elegans. The research employs genetic,...
Yale University received a $698,032 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026, through April 30, 2031. The award funds research on centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging, with the primary deliverable being scientific research and analysis aimed at understanding chromosome segregation errors in mammalian oocytes that lead to infertility, miscarriage, and developmental disorders such as Down syndrome. The funded research integrates multiple analytical methodologies—including TRIM-away-mediated protein depletion, synthetic oocyte aging platforms, and quantitative high-resolution live imaging assays—to investigate how centromere proteins (CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to protect chromosome segregation. Two primary research aims include identifying how kinetochore components support kinetochore function and spindle assembly checkpoint signaling (Aim 1), and revealing how centromeric DNA differences and the CENP-B-CENP-C axis contribute to chromosome-specific missegregation (Aim 2). Research will be conducted at Yale University's New Haven, Connecticut location and is expected to yield findings applicable to understanding age-sensitive reproductive health mechanisms.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $698.0k | 6/25/26 |