Project Grant R01HD117786
- The federal Project Grant award, totaling $654,671.00, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports a research project at Yale University examining the role of decidual extracellular vesicles in mediating placental insufficiency, a central feature of obstetrical diseases like fetal growth restriction and preeclampsia. The key...
- This federal Project Grant award, valued at $739,487 and issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to refine the understanding of immune heterogeneity in pediatric sepsis-induced multiple organ dysfunction syndrome (SIMODS). The primary objectives are to: (1) define specific functional immune endotypes and refine the heterogeneity...
- This Project Grant award of $460,625.00 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research focused on understanding the mechanisms of hematopoietic (blood) stem cell development during fetal life. Specifically, the research aims to address gaps in knowledge about the emergence and expansion of hematopoietic stem cells in...
- This Project Grant award, valued at $636,982.00 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to comprehensively investigate the proteolytic mechanisms that govern the regulation of Factor VIII (FVIII) before and after activation. The goal is to understand how proteolysis of FVIII or FVIII/von Willebrand Factor (VWF) modulates plasma FVIII concentration, as well as the physiological relevance of activated protein...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of TLR7/8-activating microRNAs in mediating fetal inflammatory response syndrome and preterm birth. The $132,779 award to Yale University, which commenced on May 1, 2025 and is expected to conclude by March 31, 2027, aims to determine if...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $765,622 to Yale University, with a sub-award to the Children's Hospital of Philadelphia, to develop orally bioavailable protein degraders targeting fetal hemoglobin gene repressors. The goal is to elevate fetal hemoglobin levels and prevent erythroid sickling to treat sickle cell disease. The award period runs from January 1, 2025 to November 30, 2028....
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $249,000.00 to the University of Connecticut Health Center to study the transcriptional regulation and intercellular signaling at the maternal-fetal interface. The research aims to understand how dysregulation of placental invasion can underlie invasion-related maternal-fetal diseases such as...
- This $163,145 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of microRNAs in placental development and fetal growth restriction (FGR). The principal investigator will model metabolic stress associated with FGR by culturing extravillous trophoblasts in nutrient-restricted media, and analyze the...
- This $168,048 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by Dr. Sean Gu at Yale University to investigate platelet immune mechanisms in sickle cell disease. The proposed research aims to characterize the heterogeneous states of platelets in sickle cell disease using novel high-throughput methods and analyze blood specimens from sickle cell disease patients as well as...
- This Project Grant award of $249,000.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to understand the impact of fetal growth restriction (FGR) on the development of non-communicable diseases like cardiovascular disease, hypertension, obesity, and diabetes. The award, with a performance period from July 1, 2025 to June 30, 2028, will...
This federal Project Grant award of $644,061 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to Yale University supports research to investigate the role of unfolded protein response in platelet dysfunction associated with pediatric multiple organ dysfunction syndrome (MODS). The research aims to determine the effects of endoplasmic reticulum stress due to inflammation on platelet unfolded protein response activation and dysfunction in pediatric MODS, as well as the underlying molecular mechanisms and potential diagnostic/therapeutic implications. This 5-year project starting in August 2025 seeks to advance understanding of how platelet dysfunction contributes to the thrombosis, thrombocytopenia, and mortality associated with MODS in children.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $644.1k | 8/21/25 |