Project Grant R01HD116856
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", provides $125,814 to support research on quantifying germ cell lineage dynamics in mammalian oogenesis (female egg cell development). The award aims to characterize the process of germ cell selection and the functional importance of early germ cell heterogeneity in shaping the developing ovarian...
- This $221,448 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to determine the role of apoptosis (programmed cell death) in oogenesis and oocyte (egg cell) health. The research will be conducted by the University of North Carolina at Chapel Hill using the oogenic germline of the model organism Caenorhabditis elegans. The goal is to...
- The Trustees of Columbia University in the City of New York was awarded a $638,625.00 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) on August 21, 2025. The project, titled "In Vivo Regulation of Progenitor Genome Organization and Cellular Diversity", aims to investigate how the physical organization of the genome in neural progenitor cells impacts their ability to generate diverse neuronal subtypes during brain...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand how calcium triggers the transition from a mature egg cell to an embryo. The $335,955 award to Cornell University, effective December 9, 2024, will fund a 5-year investigation into the post-translational mechanisms that mediate this critical...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $595,864 Project Grant to the Magee-Womens Research Institute and Foundation in Pittsburgh, PA, effective August 15, 2025 and scheduled for completion on May 31, 2030. The grant, awarded under the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to elucidate the role of hyaluronan, a key extracellular matrix component, in the development...
- The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
- This federal Project Grant award of $413,118.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research on organelle transport and organization in mammalian oogenesis. The research aims to continue investigating how primary oocytes are determined among fetal germ cells during oocyte differentiation, as well as the mechanisms underlying primary oocyte quiescence and loss in adult...
- This Project Grant award, totaling $419,014, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to investigate the role of the transcription factor SOX9 in regulating the ovulatory process and corpus luteum development in the human ovary. The research aims to provide critical insights into the mechanisms underlying...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $497,689 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The goal of this 5-year project is to investigate a novel role for actin in ensuring mitotic fidelity during early mammalian development. The researchers will...
The Trustees of Princeton University was awarded a $458,236 Project Grant by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The purpose of this 5-year grant, awarded on August 9, 2025, is to investigate the mechanisms responsible for the formation and selection of oocytes (egg cells) within the germline cysts of female mice. The researchers will develop novel genetically-encoded fluorescent reporter mouse lines and use advanced live-imaging techniques to directly visualize and understand the dynamic processes of cyst formation and oocyte selection with unprecedented detail. This research aims to elucidate the conserved and variable features of these critical developmental processes across mammals, building upon prior studies in model organisms like Drosophila.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.2k | 8/9/25 |