Project Grant R01HD119141
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $384,578 to Children's Research Institute under the Oral Diseases and Disorders Research program (CFDA 93.121) effective August 14, 2025, through August 13, 2027. This Project Grant supports basic research to identify and characterize genomic regulatory elements—specifically enhancers and their associated transcription factors—that control gene expression during lip and palate development and...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $646,212 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective July 1, 2025, through April 30, 2030. The grant supports research investigating the role of primary cilia and the centriolar protein C2CD3 in craniofacial skeletal development. This research addresses Oral-Facial-Digital...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $605,123 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 1, 2026, with completion targeted for March 31, 2030. This research project investigates the regulation of palatal innervation and its relationship to cleft palate development and repair outcomes. The research addresses a significant...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded $434,500 to the Research Institute at Nationwide Children's Hospital under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period August 1, 2025, through July 31, 2027. The funded project, "NEOGX-III: Interpretable Machine Learning with Integrated Analysis of Maternal & Infant Electronic Medical Records for Unbiased Prediction of...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Lawrence Berkeley National Laboratory $2.74 million under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop foundational research resources addressing midface developmental anomalies, including cleft lip and palate. The award, effective July 1, 2025 through March 31, 2030, will produce a single-cell multimodal atlas of human craniofacial development at critical...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $637,820 to the Research Institute at Nationwide Children's Hospital on June 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project grant supports forward genetic analysis research designed to identify novel genes influencing forebrain neurodevelopment, with specific emphasis on cortical structure, lamination, and...
- Federal Grant Award Summary The University of Washington received a $698,290 Project Grant from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct functional studies of non-coding DNA variants associated with orofacial cleft risk. The award, which commenced June 1, 2026, and concludes February 28, 2031, focuses on identifying and characterizing the pathogenic mechanisms underlying...
- Federal Project Grant Award Summary Boston Children's Hospital received a $674,620 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025 through August 31, 2027. The award supports investigator-initiated research to elucidate the genetic and developmental basis for coordinated limb growth and proportion regulation. The research employs integrated...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $462,538 Project Grant to Magee-Womens Research Institute and Foundation under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period of June 1, 2026 through May 31, 2028. The award funds research investigating CHD7-dependent regulation of migration and morphogenesis in the context of CHARGE syndrome, a congenital developmental disorder...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion targeted for July 31, 2027. The grant supports the development and application of microglia-integrated brain organoids for modeling neuronopathic Gaucher disease (NGD) and...
The Research Institute at Nationwide Children's Hospital received a $644,771 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2026 through February 28, 2031. This research initiative will employ forward genetics methodology using N-ethyl-N-nitrosourea (ENU) mutagenesis in mice to identify novel genes and genetic variants critical to craniofacial development. The project addresses a significant public health gap, as congenital craniofacial defects affect approximately 1 in 33 births, with cleft lip and palate occurring in roughly 1 in 700 births, making them among the most common structural birth defects in children. The research will generate new genetic discoveries through an unbiased, phenotype-to-genotype screening approach that may reveal fundamental insights into the genetics of craniofacial and brain development. Specifically, the study will investigate the role of the Hedgehog signaling pathway during embryonic development and conduct in-depth analysis of the P4HB gene, previously identified as crucial for proper palate and skeletal development. The anticipated outcomes include the identification of genetic determinants controlling craniofacial development that can inform future clinical applications and therapeutic interventions for birth defect prevention and treatment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $644.8k | 5/26/26 |