Project Grant R21HD119083
- This $803,958 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of an innovative approach to deliver a more biologically stable form of the enzyme acid β-glucosidase (GCase) through the blood-brain barrier into the central nervous system. The goal is to enable treatment for neuronopathic Gaucher disease, a...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 24-month, $430,375 Project Grant (CFDA 93.853) to Emory University to develop human organoid models for pediatric high-grade gliomas (PHGGs). The research aims to 1) create PHGG organoid models using human patient-derived cancer stem cells and 2) model how interactions between PHGG cells and the human neural microenvironment affect responses to tyrosine kinase inhibitors and other anti-tumor drugs. The goal is to...
- The Children's Hospital Medical Center in Cincinnati, Ohio was awarded a $510,390 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, with a performance period from May 10, 2025 to March 31, 2030, supports the hospital's research program to determine how homeodomain transcription factors specify different developmental outcomes despite binding highly similar DNA sequences. The research...
- The National Institute of Child Health and Human Development (NICHD) awarded a $434,500 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Research Institute at Nationwide Children's Hospital. The grant, titled "NEOGX-III: Interpretable Machine Learning with Integrated Analysis of Maternal & Infant Electronic Medical Records for Unbiased Prediction of Need for Genome Sequencing in Level III NICUs," aims to develop a machine...
- The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant of $107,948 to New York University (NYU) on June 20, 2025 under the Child Health and Human Development Extramural Research (CFDA 93.865) program. The grant aims to enhance the understanding of motor neuron differentiation, which is critical for addressing spinal muscular atrophy and amyotrophic lateral sclerosis - neurological disorders affecting nearly 1 in 10,000 people globally. The research will...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $148,880 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Children's Hospital Medical Center in Cincinnati, Ohio. The grant, running from May 2025 to May 2028, supports research to better understand the molecular and genetic requirements for developing the neuronal breathing circuitry, with the goal of creating targeted therapies for...
- This $161,500 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant is intended to establish basic science-clinical collaborations to understand the molecular mechanisms of heterotaxy, a severe form of congenital heart disease that affects 3-4% of patients with congenital heart defects. The funding will support research at the University of Virginia to...
- The federal Project Grant award of $719,498 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) supports research at The Children's Hospital of Philadelphia Research Institute to elucidate the neurobiological functions of glycosylation and its role in congenital disorders of glycosylation (CDG). The research aims to identify the neurological impacts of disrupted...
- The National Institute of Child Health and Human Development (NICHD) awarded a $481,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The grant, awarded on September 1, 2024, will support research to investigate the mechanisms of neuroinflammation and perinatal brain injury associated with intrauterine infection by the bacteria Ureaplasma parvum. Specifically, the project aims to assess...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $630,107 to Childrens Hospital Medical Center in Cincinnati, Ohio to investigate the role of HLA-C in chronic chorioamnionitis (CCA), a condition involving inflammation of the placental membranes. The research aims to determine how cytotoxic CD8 T cells contribute to...
The National Institute of Child Health and Human Development (NICHD) awarded a $441,375 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Children's Hospital Medical Center in Cincinnati, Ohio. The project aims to develop "Microglia-Integrated Brain Organoids for Gaucher Disease Modeling and Therapeutic Discovery". The grant will support the creation of brain organoid models that incorporate microglia to study the mechanisms of Gaucher's disease, a rare genetic disorder that can cause neurological complications. The research is intended to provide insights into the role of microgial dysfunction in Gaucher's disease pathogenesis and enable the evaluation of potential therapeutic approaches. The project will be conducted from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.4k | 8/1/25 |