Project Grant R01HD119022
- Federal Project Grant Award Summary The University of Southern California received a $451,259 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through June 30, 2029. This award supports fundamental research investigating heterochromatin repair mechanisms from a chromatin perspective. The project will deliver scientific discoveries addressing how chromatin...
- Federal Grant Award Summary The University of Southern California received a $157,052 Project Grant awarded April 9, 2026, from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research examining prenatal and parenting influences on school-age executive function, with emphasis on separate and joint maternal and paternal contributions to child development. The project, which...
- Federal Grant Award Summary The University of Southern California received a $747,000 Project Grant awarded on August 1, 2025, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The three-year project, extending through July 31, 2028, will conduct comprehensive research investigating the genetic and genomic influences on human milk composition and their impacts on infant health. The...
- Federal Grant Award Summary The University of South Carolina received a $419,459 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) beginning September 10, 2025, and concluding August 31, 2030. This P50 Center grant supports a comprehensive, lifespan-based research initiative titled "Translation of the FMR1 Premutation Phenotypes Across the Lifespan" designed to...
- Federal Grant Award Summary The University of Southern California received a $456,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective February 15, 2026, with a completion date of December 31, 2030. The award funds a five-year research initiative investigating the mechanism and function of XIST, a long non-coding ribonucleic acid (lncRNA), in maintaining X chromosome...
- Federal Grant Award Summary Princeton University's Office of Research and Project Administration received a $1,374,708 Project Grant from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 9, 2025, with a completion date of April 30, 2030. The award funds fundamental research into the mechanisms governing female germline cyst formation and oocyte selection in mice, with investigations...
- Federal Project Grant Award Summary The University of Chicago received a $444,788 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through February 28, 2031. This five-year research initiative focuses on deciphering piRNA (Piwi-interacting RNA)-based immunity mechanisms in germ cells, with emphasis on understanding how germ cells distinguish self from non-self...
- Federal Grant Award Summary The University of Southern California received a $241,032 project grant from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period September 1, 2025, through June 30, 2027. The grant funds a two-year research study examining associations between neurophysiological discrimination and clinically observable sensory reactivity features in infants at varying risk...
- Federal Project Grant Award Summary The University of Pennsylvania received a $247,138 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2028. The award funds investigator-initiated research to examine the role of the KIF2C protein in regulating microtubule cytoskeleton dynamics during the oocyte-to-embryo transition in...
- Federal Project Grant Award Summary The University of California, Davis received a $128,898 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion scheduled for July 31, 2027. This award funds research investigating the three-dimensional (3D) genome-based transcriptional program governing male germline differentiation during...
The University of Southern California received a $347,919 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026, through March 31, 2031. This award funds investigator-initiated research to decipher the function of arginine/glycine (RG) motifs in Piwi-Interacting RNA (piRNA)-mediated silencing and their role in transgenerational fertility using Caenorhabditis elegans as a model organism. The research addresses a fundamental gap in understanding how RG motifs in argonaute proteins (PRG-1 and HRDE-1) regulate piRNA-dependent gene silencing and maintain germline fertility across animal species. The project will deliver peer-reviewed scientific research examining the molecular mechanisms by which RG motifs function in the piRNA pathway, including their roles in liquid-liquid phase separation, protein-protein interactions, RNA binding, and arginine methylation. Preliminary data generated by the research team indicates that RG motifs in both PRG-1 and HRDE-1 are subject to methylation, and their mutation results in fertility and small RNA-related defects. Findings from this research will advance understanding of reproductive biology and developmental processes with potential implications for human fertility and health.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $347.9k | 6/4/26 |