This federal Project Grant award of $980,400 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support research conducted by Kent State University to investigate the role of kisspeptin/neurokinin B/dynorphin (KNDY) neurons in an animal model of polycystic ovary syndrome (PCOS). The research aims to use in vivo calcium imaging to define if increased luteinizing hormone (LH) pulse frequency in PCOS is...
This $240,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the role of altered SMAD signaling in driving ovarian defects and metabolic dysregulation in Polycystic Ovary Syndrome (PCOS). The research, conducted by Baylor College of Medicine, leverages a newly discovered SMAD variant in a PCOS patient and her daughter to analyze...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $178,000.00 to support research examining the effects of maternal genetic risk factors for polycystic ovary syndrome (PCOS) on birth and childhood outcomes in offspring. The project, awarded to The Children's Hospital Corporation (dba Boston Children's Hospital), aims to determine how maternal PCOS...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $752,491 to Kent State University to conduct research on the neural circuits mediating pulsatile and surge GnRH secretion in female mammals. The research aims to test the hypothesis that specific subpopulations of arcuate nucleus (ARN) Kiss1r neurons are critical for episodic LH secretion,...
This $335,862 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research into the role of the melanocortin-3 receptor (MC3R) in regulating the hypothalamic-pituitary-gonadal (HPG) axis. The research will be conducted by Dr. Danielle Porter at the University of Michigan. The project aims to study the neuroendocrine function of MC3R in the physiology and...
This federal Project Grant award, ID R01HD113567, was provided by the National Institutes of Health (NIH) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $418,194 award, with a project period from August 16, 2024 to May 31, 2029, will support research at Brown University to investigate the developmental and molecular mechanisms underlying the establishment and maintenance of the ovarian follicle reserve. The research aims to better understand,...
This $154,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to identify and characterize long non-coding RNAs (lncRNAs) that are regulated during the ovulatory process in mouse granulosa cells. The primary goal is to identify the top 5 most highly LH/HCG-regulated lncRNA candidates and investigate their functional role in the ovulatory...
The National Institute of Child Health and Human Development awarded a $162,512 Project Grant to Beth Israel Deaconess Medical Center, Inc. (Bidmc) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, titled "Hypothalamic Circuitry Underlying the Circadian Control of Sexual Drive and Reproduction," aims to study how the body's circadian clock affects reproductive behavior and the underlying neural circuits in mice. The key objectives are to...
This federal Project Grant award, valued at $212,345.00 and granted by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), will support research investigating the impact of oral contraceptives on neuron-derived exosomal microRNA expression in the developing female brain. The study will recruit 60 young women (15-22 years old), including 30 using oral contraceptives and 30 naturally cycling, oral...
This federal Project Grant award, with ID R01HD114827, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $352,674 award, effective from November 15, 2024 to October 31, 2029, supports research to investigate the molecular mechanisms underlying the development of the terminal nerve, GnRH-1 neuronal migration, and olfactory bulb formation in normal and pathological...