This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
The Regents of the University of Michigan was awarded a $2,207,672 Project Grant by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund a 4-year research project to comprehensively characterize and study large palindrome arrays on autosomes and sex chromosomes in mice. The research aims to determine if these large palindrome arrays contribute to...
This $149,999 Project Grant award from the National Science Foundation's Integrative Activities (CFDA 47.083) program will support a collaborative research effort to model X-chromosome inactivation in human cells. The principal investigators from New York University, Harvard University, and the New Mexico Consortium will leverage expertise in molecular biology, genomics, computational biology, biophysics, and biomolecular modeling to investigate the complex genome organization and epigenetic...
This Project Grant award of $380,495.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the mechanisms and factors that promote aberrant DNA repair at meiotic double-strand breaks, which can lead to the formation of de novo structural variants in the germline. The research program at the Regents of the University of Michigan will address how closely spaced double-strand...
The National Institute of General Medical Sciences (NIGMS) awarded Cornell University a $400,211 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to study the role of Y chromosomes in generating and maintaining intrasexual diversity. The 5-year grant, which began on July 2, 2024 and will conclude on April 30, 2029, will leverage the unique Poecilia parae fish system to: 1) identify how Y chromosome diversity alters gene regulatory networks across the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $424,264 in funding to the Regents of the University of Michigan from June 1, 2025 to May 31, 2030. The funding will support the development of advanced quantitative analysis methods for long-read RNA sequencing, both at the bulk and single-cell level. The goal is to enable deeper investigations of gene isoforms and their...
This Project Grant award, valued at $423,036.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to better understand the molecular mechanisms underlying the biogenesis and function of pachytene piRNAs, a unique class of small RNAs found in mammalian germ cells. The research aims to elucidate how regulatory motifs direct piwi proteins to engage in piRNA biogenesis,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $275,627 from September 4, 2024 to July 31, 2029 to the Regents of the University of Michigan to decipher the evolutionary history and biological impact of human admixture. The key objectives are to: 1) develop machine learning methods to investigate archaic introgression in non-European populations; 2) model the impact of...
This Project Grant award of $128,214.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate how parental CENP-A protein levels equalize during the first cell cycle of mammalian embryogenesis. The award aims to advance understanding of the molecular origins of acquired aneuploidy, which can occur during early embryonic cell...