This Project Grant award, valued at $423,036.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to better understand the molecular mechanisms underlying the biogenesis and function of pachytene piRNAs, a unique class of small RNAs found in mammalian germ cells. The research aims to elucidate how regulatory motifs direct piwi proteins to engage in piRNA biogenesis, how the mitochondrial membrane-based piRNA processing machinery operates, and how mature piwi/piRNAs exit the processing machinery for their effector functions. This research is expected to provide novel insights into the organizing principles of the piRNA pathway and reveal new mechanisms underlying mammalian pachytene piRNA biology, which is critical for normal germ cell development, human fertility, and reproductive health. The award was granted to Michigan State University, a prominent public land-grant research university, and the project will be conducted from January 2025 through December 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $423.0k | 1/9/25 |