This federal Project Grant award, valued at $423,500.00 and granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program focused on understanding the genetic basis and molecular mechanisms of evolutionary conflicts and hybrid incompatibilities. The key objectives of this 5-year research project, which commenced on May 1, 2025, are to: Elucidate the molecular mechanisms underlying the...
This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
The National Institute of General Medical Sciences (NIGMS) awarded a $380,070 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, San Francisco (UCSF) to investigate the cellular mechanisms of meiotic chromosome pairing. The 4-year project, starting on Jul 1, 2025 and ending on Mar 31, 2029, will use live-cell imaging and genetic manipulation in budding yeast to study how active telomere-led motions and nuclear...
The National Institute of General Medical Sciences (NIGMS) awarded a $274,597 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The 5-year grant, effective August 1, 2025, supports research on proteomic and phosphoproteomic remodeling under genomic imbalance, or aneuploidy. The project aims to study the mechanisms of protein regulation and signaling pathways in aneuploid cells, with a focus on distinguishing the effects of chromosome gain...
The National Institute of General Medical Sciences (NIGMS) awarded a $627,797 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University, effective May 1, 2025 through April 30, 2030. The goal of this research program is to delineate the inner workings of membrane-associated protein complexes that shape the form and function of tissues, and whose dysfunction leads to serious human diseases. The research leverages a multi-disciplinary approach...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $227,435 to the University of Rochester to conduct research on "Genetic Constraints on Adaptive Evolution". The goal is to unravel how genetic constraints limit adaptation and how these constraints diverge between species, building on the awardee's previous work characterizing constraints on thermal adaptation and...
This Project Grant from the National Science Foundation will fund $321,072 in research at the Reed Institute under the Biological Sciences federal grant program (CFDA 47.074) from March 2022 through February 2025. The research aims to investigate the evolutionary and biological basis of physical and behavioral traits that are sex-biased toward male or female expression across multiple levels of biological organization. Researchers will study global hormone levels, metabolic enzymes, hormone...
This federal Project Grant award of $616,786, awarded on June 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at uncovering the evolutionary mechanisms shaping genetic variation and phenotypic diversity across human populations. The key focus areas of the research include: 1) exploring the effects of recessive deleterious alleles and associative overdominance on patterns of...
This four-year, $1,486,812 National Science Foundation project grant supports research to advance understanding of the evolution and function of Y chromosomes in mammals. The grant funds the University of California, Riverside to produce Y chromosome assemblies and multi-tissue transcriptomes for eight rodent species, using long read sequencing and optical mapping. Gene expression atlases will be generated from long and short read transcriptomics including single cell sequencing. The research...
The National Institute of General Medical Sciences (NIGMS) awarded a $395,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Utah State University (USU) to investigate the role of structural variants in trait variation and adaptive evolution across three insect systems: Timema stick insects, Callosobruchus maculatus seed beetles, and Lycaeides butterflies. The 5-year project, starting on May 1, 2025, will combine genome assemblies, population genomic...