Project Grant R01HD118318
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $233,250 to The Washington University in Missouri to conduct research on the peripheral and central mechanisms of endometriosis pain. The key objectives are to identify the mechanisms underlying endometriosis pain and changes in pain after lesion removal surgery, focusing on...
- This federal Project Grant award, titled "INDIVIDUAL DIFFERENCES IN BRAIN MORPHOLOGY AND CONNECTIVITY TO IDENTIFY THE MECHANISMS OF COMORBIDITIES AND TREATMENT-REFRACTORY DISEASE IN FEMALES WITH ENDOMETRIOSIS-ASSOCIATED PELVIC PAIN", is provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,969,745 award to the Regents of the University of Michigan aims to use advanced neuroimaging...
- The Morehouse School of Medicine, Inc. was awarded a Project Grant of $578,397 on July 7, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to investigate the use of nitro-fatty acids as a novel therapeutic target for inhibiting the STING (Stimulator of Interferon Genes) pathway to treat the inflammation and fibrosis associated with endometriosis, a condition...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a $716,192 research project to investigate the early transcriptomic changes associated with the development of endometriotic lesions. The project, running from September 2025 to August 2030, will integrate single-cell, spatial, and bulk transcriptomics analyses of peritoneal...
- This Project Grant award, valued at $643,049.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports the development of a physiomimetic model of endometrioma, a type of endometriotic lesion, to study processes driving lesion initiation, ovarian stroma invasion, and persistence in a chronic inflammatory environment. The research aims to uncover...
- This $123,156 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a research study on the neurobiological underpinnings of chronic pelvic pain in adolescents. The key objectives are to: 1) examine personalized neural networks involved in gynecological chronic pelvic pain in adult females, 2) identify individualized trajectories of dysmenorrhea pathogenesis...
- This federal Project Grant award of $430,063 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting the development of inflammation-targeted, light-responsive nanoparticles as photoacoustic imaging contrast agents to visualize endometriosis lesions with enhanced sensitivity. The University of Delaware, the awardee, aims to develop these "nanoshells" coated with...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to study structural and functional differences in the uterotubal junction (UTJ) of women with and without endometriosis using optical coherence tomography (OCT) imaging. The $250,206 award, with a performance period from Dec 3, 2024 to Jun 2, 2028, will enable the development of a...
- This Project Grant award of $444,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The researchers at the University of Virginia will use mouse models to measure pain responses and neuronal activity during experimentally-induced migraine...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $506,000.00 to the Scripps Research Institute to define the structure-interactome relationships of the basigin glycoprotein in endometriosis. The research aims to apply proximity labeling technologies to map the interactome of basigin, a glycoprotein found to contribute to...
This Project Grant award of $378,473 from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) is focused on delineating the role of the ALDH2 enzyme in endometriosis-associated pain. The research will be conducted by Emory University and aims to: 1) determine the role of reactive aldehyde detoxification by ALDH2 in endometriosis-related pain in a mouse model, and 2) evaluate the impact of the ALDH2*2 genetic mutation on endometriosis symptoms, particularly in Asian women who exhibit higher prevalence of severe symptoms. The project will leverage preliminary data showing decreased ALDH2 activity and increased oxidative stress in the endometrial tissue of women with endometriosis and pelvic pain. Findings from this research could lead to the development of improved diagnostic and targeted therapeutic strategies for women suffering from endometriosis, which affects approximately 200 million women worldwide. The award period is from August 1, 2025 to April 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/22/25 | ||
| Not listed | $378.5k | 7/31/25 |