Project Grant R01HD117775
- This $123,156 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a research study on the neurobiological underpinnings of chronic pelvic pain in adolescents. The key objectives are to: 1) examine personalized neural networks involved in gynecological chronic pelvic pain in adult females, 2) identify individualized trajectories of dysmenorrhea pathogenesis...
- This Project Grant award of $378,473 from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) is focused on delineating the role of the ALDH2 enzyme in endometriosis-associated pain. The research will be conducted by Emory University and aims to: 1) determine the role of reactive aldehyde detoxification by ALDH2 in endometriosis-related pain in a mouse model, and 2) evaluate the impact of the ALDH2*2 genetic mutation on endometriosis symptoms, particularly in...
- This Project Grant award of $444,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The researchers at the University of Virginia will use mouse models to measure pain responses and neuronal activity during experimentally-induced migraine...
- The Regents of the University of Michigan, through its Office of Research and Sponsored Projects, was awarded a $1,425,183 Cooperative Agreement from the National Institute of Neurological Disorders and Stroke (NINDS) on September 19, 2025. The federal grant, under CFDA Program 93.279 - Drug Use and Addiction Research Programs, will fund a "SMART DESIGN STUDY USING PATIENT-BASED ALGORITHMS FOR MULTICOMPONENT THERAPY IN CHRONIC LOW BACK PAIN AND BEYOND" project. The goal of this...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $233,250 to The Washington University in Missouri to conduct research on the peripheral and central mechanisms of endometriosis pain. The key objectives are to identify the mechanisms underlying endometriosis pain and changes in pain after lesion removal surgery, focusing on...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a $716,192 research project to investigate the early transcriptomic changes associated with the development of endometriotic lesions. The project, running from September 2025 to August 2030, will integrate single-cell, spatial, and bulk transcriptomics analyses of peritoneal...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279), provides funding of $196,560.00 to the University of Michigan to conduct research on the neural responses to reward and threat in individuals with a history of childhood adversity. The research aims to identify predictive neurosignatures that can inform novel targeted intervention strategies for substance use...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $421,437 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Minnesota. The grant supports research to investigate sex differences in spinal dopaminergic mechanisms underlying neuropathic pain. The project aims to define the function of dopamine 1 receptors (DRD1) expressed in dorsal horn neurons and their role in nerve...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
This federal Project Grant award, titled "INDIVIDUAL DIFFERENCES IN BRAIN MORPHOLOGY AND CONNECTIVITY TO IDENTIFY THE MECHANISMS OF COMORBIDITIES AND TREATMENT-REFRACTORY DISEASE IN FEMALES WITH ENDOMETRIOSIS-ASSOCIATED PELVIC PAIN", is provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,969,745 award to the Regents of the University of Michigan aims to use advanced neuroimaging techniques to explore the relationship between brain morphology, connectivity, and treatment outcomes for females with endometriosis-associated pelvic pain. The project will synthesize data from multiple existing R01 studies at the University of Michigan, as well as population-based samples, to develop, refine, and validate computational models that can reveal novel patient subtypes and treatment response predictors. The ultimate goal is to enhance understanding of the central mechanisms underlying the heterogeneity in clinical presentations and treatment responses observed in this condition. The project period is from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 8/19/25 |