Project Grant R01HD117902
- Federal Project Grant Award Summary Yale University received a $1.85 million Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) on August 15, 2025, with a completion date of April 30, 2030. The award funds research into the mechanisms regulating chromatin organization and epigenetic memory during early vertebrate development. The research aims to elucidate how the...
- Federal Grant Award Summary Yale University received a $1,280,711 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025 through April 30, 2030. This research initiative investigates the role of decidual extracellular vesicles (EVs) in mediating placental insufficiency, a pathological condition underlying obstetrical diseases including fetal growth...
- Federal Grant Award Summary Yale University received a $158,766 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through March 31, 2029. The award supports research investigating how endometriosis impacts decidualization and trophoblast-endometrial interactions during human implantation. The research delivers a novel patient-derived...
- Federal Grant Award Summary Yale University received a $537,696 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. The award supports fundamental research investigating the coordination of germline chromatin organization mechanisms that initiate embryogenesis. The research employs genetic, molecular, and genomic tools to examine how germ...
- Federal Grant Award Summary Yale University received a $2.25 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded on August 8, 2025, with a completion date of April 30, 2030. The research project focuses on elucidating the genetic, cellular, and molecular mechanisms underlying reduced sperm motility in male infertility. The investigative team will conduct...
- Federal Grant Award Summary Yale University received a $266,945 Project Grant from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective May 1, 2025 through April 30, 2030. The award funds the Yale Maternal, Newborn and Child Health Promotion (MNCHP) Training Program, a T32 institutional training initiative designed to develop the next generation of maternal, newborn, and child health...
- Federal Grant Award Summary Yale University received a $460,740 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award funds research to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states. The primary deliverables include the application of Proteolysis-Targeting...
- Federal Grant Award Summary Yale University received a $1.93M Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 25, 2025, through April 30, 2030. The project, titled "Platelet Dysfunction in Pediatric Multiple Organ Dysfunction Syndrome: Role of Unfolded Protein Response," focuses on advancing understanding of how endoplasmic reticulum (ER)...
- Yale University received a $460,625 Project Grant award dated August 11, 2025, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research initiative, with a completion date of July 31, 2027, focuses on elucidating the mechanisms of hematopoietic stem cell (HSC) development during fetal life in mice. The project addresses critical gaps in understanding how endothelial cells...
- Federal Project Grant Award Summary Yale University received a $248,975 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 28, 2025, with completion scheduled for July 31, 2028. This award supports basic biomedical research investigating stress response signaling as a metabolic sensor in reproduction, with research performance occurring at Yale's Pittsburgh, PA facility....
Yale University received a $627,603 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2026, through February 28, 2031. The award funds research investigating metabolic signaling mechanisms that control mammalian embryonic patterning, specifically focusing on how glucose metabolism instructs cell fate decisions and morphogenetic behaviors during gastrulation. The research employs multi-omics approaches, including cell type-resolved isotope tracing and high-resolution two-photon live imaging in transgenic mouse embryos, to elucidate how glucose-derived metabolic intermediates regulate FGF (fibroblast growth factor)/ERK (extracellular signal-regulated kinase) signaling pathways during the epiblast-to-mesoderm transition. The project delivers fundamental scientific products through two coordinated research aims: (1) determining how the hexosamine biosynthetic pathway links glucose metabolism to ERK activation during mesoderm specification through proteomics assays and genetic perturbations, and (2) establishing causal relationships between metabolic states and morphogenetic cell movements during gastrulation. Research will be conducted at Yale University's New Haven, Connecticut campus using mouse embryos, embryo-derived tissue explants, and in vitro stem cell-based models to generate novel insights into developmental biology and the instructive role of metabolic signaling in early mammalian development.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $627.6k | 5/25/26 |