Project Grant R01HD115952
- This $697,256 project grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to identify distinct subphenotypes and endotypes in children with sepsis-induced multi-organ dysfunction syndrome (MODS). The study, titled "Discovering Subphenotypes and Endotypes in Pediatric Sepsis-Induced MODS: The DISPENSE Study", will leverage data from two...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support an early-stage investigator at Case Western Reserve University (CWRU) to investigate the role of heme dysregulation in the innate and adaptive immune response of patients with sepsis or chronic hemolytic diseases. The $402,500 award, with a performance period from August 1, 2025 to July 31, 2030, aims to establish new...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $179,475 to The Children's Hospital of Philadelphia (CHOP) to conduct research on pediatric sepsis. The key objectives of the project are to define and validate a molecular subphenotyping model that can predict the severity of sepsis in children, and to test the reversibility of immune dysregulation through targeting...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $721,728 to the Regents of the University of Michigan to conduct research on "Modulation of Pediatric Sepsis by Virus Persistence." The research aims to identify novel biomarkers that can help define sepsis phenotypes and predict patient responses to immunomodulatory therapies. Specifically, the study will investigate how persistent...
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This Project Grant award of $186,221 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to develop personalized therapies for pediatric sepsis. The primary objectives are to augment sepsis phenotypes through the integration of high-frequency physiologic data with electronic health record data, and to retrospectively identify sepsis subtypes that may respond differently to various...
- This federal Project Grant award of $422,125 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to assess whether multi-omic data of myeloid-derived suppressor cells (MDSCs) can improve sepsis endotyping and predict clinical trajectories in chronic critical illness (CCI) after sepsis. The overarching goal is to better understand the role of "pathologic myelopoiesis" and MDSC...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will provide $167,400.00 to the University of Utah to conduct research on optimizing the dosing of the drug anakinra for the treatment of children with sepsis-induced multiple organ dysfunction syndrome (MODS). The key objectives of the research are to: 1) characterize the kinetics of endogenous...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $418,750.00 to The Feinstein Institutes for Medical Research to conduct research on T cell receptor-mediated T cell activation in neonatal and pediatric sepsis. The goal is to gain insight into how T cell memory influences sepsis-associated organ dysfunction, by comparing responses between human neonates with sepsis and...
- The Research Foundation for the State University of New York received a $108,512 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to develop novel immune-modulating itaconate-loaded telodendrimer nanoparticles to target both hyperinflammation and pyroptosis in sepsis. The project aims to address the current gap in therapies that can directly mitigate excessive cytokine production and immune cell pyroptosis,...
This Project Grant award of $739,487.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to refine the understanding of immune heterogeneity in pediatric sepsis-induced multiple organ dysfunction syndrome (SIMODS). The key objectives are to: (1) define specific functional immune endotypes and refine the heterogeneity over time in immunosuppressive or hyperinflammatory phenotypes, and (2) identify immunomodulatory molecules that can effectively restore normal immunity against these endotypes. This work will help close critical knowledge gaps, increase data collection on innate and adaptive immune markers in MODS, and improve the design of targeted clinical trials for immune stimulation or suppression therapies. The award was made to Case Western Reserve University, a prominent private research institution, and the project will be conducted in Cleveland, OH. The performance period runs from August 1, 2025 through April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $739.5k | 7/28/25 |