Project Grant K08HL175198
- The federal Project Grant award in the amount of $503,870.00 was provided by the National Heart, Lung, and Blood Institute (CFDA Program 93.837 - Cardiovascular Diseases Research) to Drexel University. The award is focused on developing a mechanistic understanding of how fetal hemoglobin (HbF) modulates the polymerization of sickle cell hemoglobin (HbS), which is the root cause of sickle cell disease. The research aims to address critical knowledge gaps that limit the rational optimization of...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $765,622 to Yale University, with a sub-award to the Children's Hospital of Philadelphia, to develop orally bioavailable protein degraders targeting fetal hemoglobin gene repressors. The goal is to elevate fetal hemoglobin levels and prevent erythroid sickling to treat sickle cell disease. The award period runs from January 1, 2025 to November 30, 2028....
- This Project Grant award, valued at $465,000.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research to investigate the mechanisms by which chronic inflammation disrupts the hemostatic balance in sickle cell disease (SCD). Specifically, the project aims to understand how tumor necrosis factor-alpha (TNFa) induced inflammation blocks autophagy and mitophagy in platelets and...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,276,908 in funding to Bloodworks, a non-profit organization based in Seattle, Washington. The award, effective March 1, 2025 through February 28, 2032, supports molecular and translational research studies focused on hematological disorders, specifically von Willebrand disease and sickle cell disease. The research aims to...
- The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research program (CFDA 93.837), awarded a $779,952 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to investigate the role of platelets in regulating non-neurological complications of ischemic stroke. The 4-year project, running from June 2025 to March 2029, aims to gain a deeper understanding of how activated platelets contribute to remote organ injury and...
- This federal Project Grant award for $111,626.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate macrophage populations and their role in pulmonary hypertension associated with sickle cell disease. The 2-year research project aims to determine if targeting iron release can modify CD169+ macrophages and adaptive immune cells, and if ablation of CD169+ macrophages can inhibit the progression of...
- The University of Rochester was awarded a $573,261 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to investigate the role of platelets in regulating monocyte immune responses during vascular inflammation. The 4-year research project, beginning August 1, 2025, aims to understand how resting platelets interact with monocytes to epigenetically "train" their innate immune responses, and how this process is altered by platelet...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $536,468 to the University of California, San Diego (UC San Diego) to conduct research on protein aggregation in hematopoietic stem cells (HSCs). The project aims to investigate how HSCs, which regenerate blood and immune cells, preferentially traffic misfolded proteins to aggresomes to maintain fitness and self-renewal, and how this process is impacted by...
- This Project Grant award of $154,796.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Vanderbilt University Medical Center aims to use non-invasive neuroimaging techniques to investigate cerebral oxygen utilization in patients with sickle cell disease. The goal is to develop biomarkers that can be used to assess ischemic risk and evaluate the impact of emerging treatments on brain health. The project will explore how abnormal...
- This federal Project Grant award of $761,028 from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 Cardiovascular Diseases Research will support a multi-site prospective study on hypoxemia during sleep in adults with sickle cell anemia (SCA). The study aims to examine the prevalence, clinical impact, and response to treatment of sleep-related hypoxemia in this patient population across four institutions, including both urban and rural sites. Key activities will involve...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $168,048 to Yale University to conduct research on investigating platelet immune mechanisms in sickle cell disease. The primary goals are to 1) characterize heterogeneous platelet subpopulations and their contribution to vaso-occlusive disease in sickle cell patients, and 2) investigate specific immunothrombotic pathways and mechanisms of platelet activation and dysfunction. This 5-year research project, led by Dr. Sean Gu, aims to advance the understanding of sickle cell disease pathogenesis and identify potential targets for novel therapies. The award commenced on September 15, 2025 and is scheduled for completion on June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $168.0k | 9/15/25 |