Project Grant R01HD117197

Award Date 4/22/25
Completion Date 3/31/30
Dollars Obligated $658K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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This Project Grant award, totaling $682,076.00, is funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to study human milk as a biological system, examining its composition, dynamics, and delivery methods (at-the-breast vs. expressed milk) to improve infant health. The interdisciplinary research team will collect daily human milk samples and metadata from 120...
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This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) totaling $657,909 will support research on the impact of maternal exercise during lactation on human milk composition and infant metabolism. The award to the Joslin Diabetes Center, Inc. will fund a study with the following key objectives:

  1. Measure changes in thermogenic metabolites and lipids in human milk in response to a single exercise session and an 8-week physical activity intervention in 100 breastfeeding mother-infant pairs.

  2. Analyze the effects of maternal exercise-induced changes in milk-derived mammary epithelial cells on milk composition.

  3. Link maternal exercise-induced changes in human milk to immediate and long-term metabolic and body composition outcomes in the infants.

This research aims to elucidate the mechanisms by which maternal exercise during lactation may protect against childhood obesity by modulating the composition of breast milk. The 5-year project period runs from April 2025 to March 2030.

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