Project Grant K99HD113834

Award Date 8/9/24
Completion Date 7/31/26
Dollars Obligated $129K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Minneapolis, MN 55455, USA
Similar Awards
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $756,745.74 to the Regents of the University of Minnesota to conduct research examining the relationship between maternal stress, human milk composition, and neurodevelopmental and feeding outcomes for preterm infants. The award period runs from August 16, 2024 to July 31, 2027. The proposed research...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $269,263 to investigate methods for reducing the risk of postnatal cytomegalovirus (CMV) infection in preterm infants exposed to CMV-positive breast milk. The two key objectives are: 1) Evaluating the pharmacokinetics and neutralizing efficacy of an anti-CMV antibody added to CMV-positive breast milk, and 2) Characterizing...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a biomimetic, 3D mammary lobe system that can faithfully replicate in vivo breast milk synthesis processes. The $154,796 award, effective April 1, 2025 through July 31, 2027, will enable the principal investigator at the Massachusetts Institute of Technology (MIT) to pursue two key objectives:...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $246,390 to Cornell University to conduct research on the regulation of human milk production and its relationship with infant growth. The key objectives are to: Characterize the function of the gene C6ORF15 and its role in increasing milk production using cell line and mouse models. Explore factors...
The National Institute of Child Health and Human Development (NICHD) awarded a $451,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the therapeutic potential of maternal breast milk components for preterm white matter injury (WMI). The key objectives are to: 1) Perform high-throughput screening of breast milk components to identify pro-myelinating compounds, and 2) Test...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a comparative study investigating the mechanistic effects of human milk feeding on neurodevelopment in preterm infants. The $239,399 award to the Regents of the University of Idaho will utilize a neonatal piglet model to examine how human milk feeding influences intestinal barrier function,...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,538,070 to the Regents of the University of Minnesota to study the role of mitochondrial nutrient transport in regulating trophoblast differentiation. The research aims to reveal novel, nutrient-responsive mechanisms controlling epigenetic and transcriptional reprogramming events foundational to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, totaling $309,496, will fund research at Duke University to investigate the role of gene regulatory networks in neonatal nutrition and immunity. The key objectives of this 2-year project are to: 1) leverage bioinformatic analysis and genetic mouse models to define the gene regulatory networks controlled by the transcription...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $751,710.10 to the University of Colorado-Denver to conduct research on the links between lactation and metabolism. The goal of the project is to identify the molecular mechanisms connecting lactation to metabolism, with the long-term aim of developing interventions to improve lactation outcomes in...
This Project Grant award, totaling $763,965, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program. The funding supports research to investigate how metal exposures during critical windows of mammary gland development may alter the microRNA (miRNA) composition of human breast milk, and how these changes could contribute to accelerated growth and increased risk of obesity in early childhood. The...

This $128,817 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Regents of the University of Minnesota supports a research project to comprehensively profile the composition of human breast milk and investigate its impacts on infant development. The project aims to identify genetic variants influencing milk metabolites, assess the effects of human cytomegalovirus reactivation in the mammary gland on the milk metabolome, and explore the impacts of milk composition on preterm infant immune system and gut microbiome development. This research leverages advanced genomics, metabolomics, and computational methods to provide foundational data for advancing the understanding of human nutrition during the critical first 1,000 days of life. The award period runs from August 9, 2024 to July 31, 2026.

Generated 7/1/25, 3:15 AM