This $502,710.55 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to identify the molecular mechanisms linking lactation to metabolism, with the goal of developing interventions to improve lactation outcomes in women with obesity and/or diabetes. The key objectives are to: 1) establish the effect of maternal gestational diabetes on mammary epithelial...
This Project Grant award, totaling $682,076.00, is funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to study human milk as a biological system, examining its composition, dynamics, and delivery methods (at-the-breast vs. expressed milk) to improve infant health. The interdisciplinary research team will collect daily human milk samples and metadata from 120...
This $284,524 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve understanding of the transcriptional basis of human milk production. The research will utilize existing single-cell RNA sequencing data from human milk to (1) identify shared transcriptional pathways of lactation, (2) develop statistical models to expose genes and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to enhance breastfeeding outcomes through digital phenotyping. The $204,611 award to Northeastern University will utilize passive longitudinal monitoring via smartphones, smartwatches, and ecological momentary assessments to examine physiological and behavioral factors during the third trimester that...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $128,817 to the Regents of the University of Minnesota to conduct research on genetic and genomic influences on human milk composition and its impacts on infant health. The key objectives are: 1) Identifying genetic variants influencing specific milk metabolites and the associated genes, as well as investigating connections...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the neurobiological and behavioral underpinnings of intergenerational obesity in humans. The $194,876 award will fund two complementary studies: a secondary analysis of an existing cohort to determine the impact of pre-pregnancy obesity on newborn regulatory behaviors...
This Project Grant award, with a total funding of $246,390, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to characterize the physiological and transcriptional factors regulating human milk production, with the goal of improving diagnosis and treatment of insufficient milk supply, a significant women's health issue. Key activities include: Characterizing the...
This federal Project Grant award, valued at $269,263 and spanning August 2024 to July 2026, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The primary objectives are to (1) evaluate the pharmacokinetics and neutralizing efficacy of an anti-cytomegalovirus (CMV) antibody added to CMV-positive breast milk, and (2) investigate the impact of mammary CMV reactivation on the...
The federal Project Grant award R01HD113596, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate how maternal exercise can rescue bone and joint development impaired by fetal akinesia (insufficient movement). The $523,064 award to The Trustees of the University of Pennsylvania, awarded on Aug 12, 2024, aims to determine the cells and signaling...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865, Child Health and Human Development Extramural Research program) to the University of Texas at Austin provides $1,226,506 in funding over the period of September 1, 2024 to May 31, 2029. The project aims to perform longitudinal MRI imaging of the maternal pancreas during pregnancy and postpartum, correlating imaging metrics with the development of diabetes in the mother. The research will also...