Project Grant R01HD116735

Award Date 8/1/25
Completion Date 4/30/30
Dollars Obligated $687K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Kentucky, USA
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  1. Test if the unique metabolic and signaling profile of macrophages associated with regenerative digit injuries is essential for regeneration, using advanced techniques like single-cell RNA sequencing.
  2. Determine whether the regenerative macrophages can promote a regenerative environment during fibrotic scarring.

The goal is to unravel the intricate role of macrophages in regeneration, with the potential to unlock their use as therapeutic targets for engineering regeneration-permissive environments. The research leverages a comparative mouse model to understand the mechanisms underlying macrophage-mediated bone and soft tissue regeneration.

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