This $497,083 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to elucidate the genetic and molecular basis of scarless, multi-lineage skin regeneration in fetal mice. The project aims to create comprehensive cellular and molecular atlases of fetal versus postnatal wound healing processes using single-cell multiomics approaches. The...
This Project Grant award, valued at $387,500.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research focused on understanding the gene regulatory networks involved in hair cell regeneration in zebrafish. The primary awardee, The Johns Hopkins University, will conduct studies to elucidate how the SOX and SIX families of transcription factors control hair cell regeneration, as well as...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $626,879 in funding to the University of Southern California (USC) to conduct research into the cellular and molecular mechanisms that enable large-scale bone regeneration. The research aims to unravel the intricate processes governing the initiation and coordination of bone repair...
This $293,550 federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) aims to establish the spiny mouse (Acomys) as a genetic model organism for regeneration research. The project, which runs from July 1, 2024 to June 30, 2026, will develop multiple genetic tools including inbred lines, embryonic stem cells, and transgenics to make the Acomys species more experimentally tractable. This will enable researchers to better...
This $1,034,838 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the role of neutrophil serine proteases in regulating the muscle stem cell niche and muscle regeneration. The research aims to define how the muscle stem cell niche is affected by the loss of neutrophil serine proteases, identify the molecular mechanisms regulated...
This $177,872 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to study the interactions between human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) and skeletal muscle progenitor cells (MPCs) both in vitro and in vivo. The key objectives are to: Investigate the paracrine effects of hiPSC-ECs on the...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $224,648 to the University of California, Irvine to conduct collaborative research on the shared genetic and cellular mechanisms underlying vertebrate limb and fin regeneration. The research aims to identify the core components of a "toolkit" for limb and fin regeneration by studying the axolotl, African lungfish, and grey bichir. Key objectives include: 1) Testing the...
This $570,878 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into modulating myofibroblast dynamics to enhance tendon healing following injury. The research aims to define the efficacy of pharmacologically activating the GPR68 receptor to regulate the transition between tenocytes and myofibroblasts during fibrotic tendon healing....
This $1,192,487 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program will support research to uncover the cellular and molecular mechanisms governing tissue regeneration in the model organism Drosophila melanogaster. The key objectives are to investigate: (i) the processes that activate and sustain the regenerative microenvironment, (ii) the gene regulatory networks driving distinct...
This $557,357 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research at the University of Wisconsin-Madison to investigate the role of HOX-expressing interstitial cells in skeletal muscle growth, homeostasis, and regeneration. The project aims to interrogate the lineage potential and functional mechanisms of this novel cell population,...