This $393,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training supports research at the University of California, Los Angeles (UCLA) to explore the fundamental cellular mechanisms that drive cellular senescence in macrophages. The award aims to provide a deeper understanding of the molecular pathways regulating macrophage senescence, including the roles of cell cycle arrest genes, metabolic...
The National Institute of General Medical Sciences (NIGMS) awarded a $541,967 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to expand the understanding of adherent cell mechanics and mechanobiology. The 5-year project, starting on January 1, 2025, aims to explore the force-sensitive remodeling of cell-cell adhesions and the role it plays in contact inhibition of proliferation. It will also investigate mechanisms of mechanosensing via LIM...
The National Institute of General Medical Sciences (NIGMS) awarded a $724,640 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Rochester Institute of Technology (RIT) to conduct research aimed at improving the understanding of cell-substrate interactions on porous membranes and advancing the development of ultrathin membranes for physiologically relevant tissue barrier and co-culture models. This five-year research program, beginning on June 1, 2024 and ending on...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a research program at Georgetown University focused on developing multiparametric fluorescence microscopy techniques. The goal is to create an integrated imaging workflow that can simultaneously measure and correlate various cellular properties such as metabolism, protein diffusion, and membrane fluidity across multiple...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), will provide $166,204 to The Medical College of Wisconsin, Inc. over a 4-year period from August 1, 2024 to July 31, 2028. The funding will support the development and advancement of cell-free DNA as a novel biomarker with predictive and prognostic roles in sepsis. The primary goal is to establish Dr. Nicholas P. Semenkovich as an...
The federal Project Grant award R35GM154869, totaling $375,430.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). This grant supports research at the University of Wisconsin-Madison to elucidate the fundamental mechanisms underpinning cellular maintenance, focusing on two key aspects: 1) investigating the control mechanisms and regulators of lysosomal degradative capacity and protein...
The National Institute of General Medical Sciences (NIGMS) awarded Central Michigan University a $443,315 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) with a start date of September 1, 2023 and an ultimate completion date of August 31, 2026. The goal of this research project is to characterize the impact of social status on oxidative stress patterns and regulation across the brain. The research will use the cichlid fish Astatotilapia burtoni as a...
This $881,450 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the CFDA 93.351 Research Infrastructure Programs is focused on developing novel humanized mouse models to support the efficient engraftment of human tissue-resident macrophages. The primary awardee, the University of Massachusetts Medical School, will work to generate genetically modified NSG-FIRE mouse strains that are deficient in mouse tissue-resident macrophages and express human...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The grant supports the development of a novel "proximity labeling" approach to map the folding and protein occupancy of entire chromosomes at single-nucleosome resolution and single-molecule precision. This methodology aims to provide a more comprehensive...
This $373,375 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to understand the fundamental mechanisms governing the interactions between ultra-small nanoparticles (USNPs) and inflammatory monocyte cells (FIMs), and how myeloid cell recruitment mediates the targeting of USNPs carrying drug payloads to sites of inflammation. The research team at the University of Florida will conduct...